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| Clinical comparative study of gonadotropin releasing hormone and Dydrogesterone Tablets in the prevention of recurrence of endometrial polyps after electrotomy |
| LI Yan WANG Juan ZHANG Renqi |
| Gynecology Clinic, the First Affiliated Hospital of Xinjiang Medical University, Xinjiang Uygur Autonomous Region, Urumqi 830000, China |
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Abstract Objective To compare the clinical effect of gonadotropin releasing hormone and Dydrogesterone Tablets in the prevention of recurrence of endometrial polyps (EMP). Methods From March 2016 to December 2018, 208 patients with EMP in the First Affiliated Hospital of Xinjiang Medical University were selected from March 2016 to December 2018, they were divided into group A (n = 104) and group B (n = 104) according to the random number table. Group A was given Dydrogesterone Tablets after operation for prevention and group B was given gonadotropin releasing hormone after operation for prevention. The endometrial thickness, quality of life scal (SF-36), serum sex hormone index, recurrence rate and adverse reactions of patients were compared between the two groups. Results There was high significant difference of endometrial thickness in time, group and interaction between the two groups (P < 0.01). Further comparison between the two groups: 3, 6 months and 12 months after the operation, the endometrial thickness of the two groups decreased in turn compared with that before the operation (P < 0.05); that of group B was lower than that of group A (P < 0.05). At 12 months after operation, SF-36 scores in both groups were higher than those before operation, and group B was higher than group A, the differences were statistically significant (P < 0.05). 12 months after operation, follicle-stimulating hormone, progesterone and estradiol in the two groups were lower than those before operation, and group B was lower than group A, the differences were statistically significant (P < 0.05). The recurrence rate in group B was lower than that in group A, the difference was statistically significant (P < 0.05). The incidence of adverse reactions in group B was higher than that in group A, the difference was statistically significant (P < 0.05). Conclusion Compared with the prophylactic treatment of Dydrogesterone Tablets, the prophylactic treatment of gonadotropin releasing hormone can effectively improve the endometrial thickness, quality of life and serum sex hormone indexes, and reduce the recurrence, but its safety is relatively poor. The specific tolerance of the patients can be seen in clinical practice.
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