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| Clinical effect of Cinobufacin Injection in the treatment of malignant pleural effusion with “damp heat toxin syndrome” |
| ZHENG Junchao1,2* ZHOU Qin2* YANG Ying2,3 JIANG Min2 ZUO Minghuan2 |
1.Graduate School, Beijing University of Chinese Medicine, Beijing 100029, China;
2.Department of Oncology, Dongfang Hospital, Beijing University of Chinese Medicine, Beijing 100078, China;
3.Department of Oncology, Tongde Hospital of Zhejiang Province, Zhejiang Province, Hangzhou 310012, China |
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Abstract Objective To explore clinical effect of Cinobufacin Injection in the treatment of malignant pleural effusion with “damp heat toxin syndrome”. Methods Thirty patients with malignant pleural effusion of “damp heat toxin syndrome” admitted to Dongfang Hospital of Beijing University of Chinese Medicine from September 2017 to March 2019 were randomly divided into treatment group and control group, with 15 cases in each group. All patients were treated with closed thoracic puncture and drainage to drain the pleural effusion. Treatment group was given Cinobufacin Injection, while control group was given IL-2 perfusion, three times a week, two weeks as a course of treatment. The quantity of pleural effusion, the quality of pleural effusion (RBC, LDH, TM), the symptom score of Chinese Medicine, KPS score and VEGF level were compared before and after treatment between two groups. Results There was no significant difference in the amount of pleural effusion between two groups (P > 0.05). The differences of RBC and TM after treatment between two groups were statistically significant (P < 0.05); the difference of LDH after treatment between two groups was not statistically significant (P > 0.05). After treatment, the symptom scores of two groups were lower than before treatment, the differences were statistically significant (P < 0.05). There was no significant difference in KPS between two groups (P > 0.05). There was no significant difference in VEGF level between two groups before and after treatment (P > 0.05). Conclusion Treatment of malignant pleural effusion with Cinobufacin Injection is related to the decrease of RBC and TM in pleural effusion, and its possible mechanism is to reduce the expression of VEGF in pleural effusion.
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