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| Clinical observation for point-injection at the back of internal sphere of high-dose Houttuyniae Herba in the treatment of herpes simplex keratitis |
| ZHANG Guanghong1，2 LUO Jihong1，2 LI Dujun1，2 YANG Changyou3 WU Lin4 |
1.Department of Ophthalmology, Hubei Provincial Hospital of Traditional Chinese Medicine, Hubei Province, Wuhan 430061, China;
2.Department of Ophthalmology, Hubei Province Academy of Traditional Chinese Medicine, Hubei Province, Wuhan 430074, China;
3.Department of Public Health, Central China Normal University Hospital, Hubei Province, Wuhan 430079, China;
4.Department of Ophthalmology, Central China Normal University Hospital, Hubei Province, Wuhan 430079, China |
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Abstract Objective To investigate clinical efficacy and safety of point-injection at the back of internal sphere of high-dose Houttuyniae Herba in the treatment of herpes simplex keratitis (HSK). Methods A prospective, randomized, controlled, single-blind study was conducted from October 2016 to September 2017 in Department of Ophthalmology, Hubei Provincial Hospital of Traditional Chinese Medicine. 120 patients (123 eyes) diagnosed with HSK were selected and divided into two groups according to the random envelope method, 60 patients (61 eyes) in control group and 60 patients (62 eyes) in experimental group. Control group was treated with Ganciclovir Eye Drops and Ganciclovir Eye Gel, while experimental group was added with point-injection of high-dose Houttuyniae Herba. All patients were treated for 15 days. Clinical efficacy, total scores of ocular symptoms and signs, the recovery of corneal sensitivity were compared, and the recurrence rate was compared with the follow-up for one year． Results After treatment, total clinical effective rate of experimental group was higher than that of control group, the difference was highly statistically significant (P < 0.01). After treatment, total score of ocular symptoms and signs in two groups was significantly lower than that before treatment (P < 0.01), and that in experimental group was significantly lower than that in control group (P < 0.01). After treatment, the corneal perception of two groups recovered significantly (P < 0.01), and corneal perception of experimental group recovered significantly (P < 0.01). The recurrence rate of HSK in experimental group was significantly lower than that in control group (P < 0.05). There was no obvious discomfort and side effects in both groups. Conclusion The double effects of Houttuyniae Herba combined with medicine and acupoint stimulation at the back of internal sphere in the treatment of HSK is significant. It can obviously improve the ocular symptoms and signs of patients, at the same time, reduce the recurrence, and the adverse reactions are slight. It is worthy of clinical application.
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