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| Clinical effect of mild hypothermia combined with cattle encephalon glycoside and ignotin in the treatment of neonatal asphyxia brain injury and the influence on blood NO |
| MU Yanshun LIU Weijuan GAO Jialing LIU Hongwei FAN Qingman |
| Department of Pediatrics, Huabei Petroleum General Hospital, Hebei Province, Renqiu 062552, China |
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Abstract Objective To investigate the clinical efficacy of mild hypothermia combined with cattle encephalon glycoside and ignotin in the treatment of neonatal asphyxia brain injury and its effect on blood NO. Methods A retrospective analysis of 62 neonates with moderate and severe asphyxia brain injury who admitted to Department of Pediatrics, Huabei Petroleum General Hospital from May 2018 to October 2019. According to the different treatment methods, they were divided into mild hypothermia combined with cattle encephalon glycoside and ignotin treatment group (31 cases) and the routine treatment group (31 cases). Symptomatic supportive treatment such as maintaining electrolyte balance, lowering intracranial pressure, anti-infection and nutritional support was given to children in routine treatment group. The children in mild hypothermia combined with cattle encephalon glycoside and ignotin treatment group were treated with mild hypothermia combined with cattle encephalon glycoside and ignotin on the basis of conventional treatment. The changes of neonatal behavioral neuropathy assessment (NBNA) were compared between two groups on 7, 14 d after treatment, and the dynamic changes of blood NO were monitored. Results There was no significant difference in NBNA score between two groups before treatment (P > 0.05). NBNA scores on 7, 14 d after treatment of two groups were higher than those before treatment, and mild hypothermia combined with cattle encephalon glycoside and ignotin treatment group was higher than routine treatment group, with statistically significant differences (all P < 0.05). There was no statistically significant difference in blood NO level between two groups before treatment (P > 0.05). Blood NO level on 7, 14 d after treatment of two groups were lower than those before treatment, and mild hypothermia combined with cattle encephalon glycoside and ignotin treatment group was lower than routine treatment group, with statistically significant differences (all P < 0.05). Conclusion Mild hypothermia combined with cattle encephalon glycoside and ignotin treatment can significantly improve NBNA score. The detection of serum NO is helpful to the judgment of brain injury after asphyxia.
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