氨基酸在炎症性肠病治疗中的研究进展

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Abstract Inflammatory bowel disease (IBD) is a chronic non-specific inflammatory disease of the intestinal mucosa with unknown etiology, including crohn′s disease and ulcerative colitis. The etiology and pathogenesis are not completely clear, and it is generally believed to be related to environment, heredity, infection and immunity. Amino acids are important nutrients in living organisms, which are essential substances for promoting intestinal growth, maintaining intestinal mucosal integrity and barrier function. Amino acids are also energy substrates for intestinal cells and the material basis for wound healing of intestinal mucosa. A large number of studies have confirmed the abnormal amino acid metabolism in the course of IBD disease, including glutamine, glutamate, arginine, tryptophan, cysteine, glycine, etc., and the supplementation of the above amino acids has a protective effect on the intestinal damage of IBD. The mechanism involves stimulating intestinal epithelial cell proliferation, inhibiting oxidative stress damage, reducing the release of pro-inflammatory cytokines, and increasing the migration capacity of epithelial cells. This article aims to explore the potential value of amino acids in the treatment of IBD by collecting relevant literature at home and abroad.

Key words： Amino acids Inflammatory bowel disease Ulcerative colitis Crohn′s disease

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	CAI Bin1 ZHOU Minhong2 LI Chunwei1▲

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CAI Bin1 ZHOU Minhong2 LI Chunwei1▲. Research progress of amino acids in the treatment of inflammatory bowel disease[J]. 中国医药导报, 2020, 17(9): 37-40.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2020/V17/I9/37

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