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| Advances in oxidative stress signaling pathways in osteoarthritis |
| HAN Guangtao LI Haohuan CAI Weisong ZHANG Yubiao |
| Department of Orthopedics, Renmin Hospital of Wuhan University, Hubei Province, Wuhan 430060, China |
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Abstract Osteoarthritis is a common joint disease in orthopedics, and its prevalence is increasing with the aging of population. The pathogenesis of osteoarthritis is influenced by multiple factors, including oxidative stress and excessive production of reactive oxygen species, which regulate intracellular signal transduction, chondrocyte aging and apoptosis, extracellular matrix synthesis and degradation, synovial inflammation and subchondral bone function. Due to relatively few drugs for osteoarthritis, this paper targeting complex oxidative stress signaling pathways could provides strategies for treating osteoarthritis.
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