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Research progress of animal model of necrosis of femoral head |
CHEN Junming1 YUE Chen2 Fan Ya′nan2 HE Peilin1 WANG Huichao2 LIU Youwen2 |
1.College of Tradition Chinese Medicine, Fujian University of Tradition Chinese Medicine, Fujian Province, Fuzhou 350001, China;
2.Center of Hip Disease Research and Treatment, Luoyang Orthopedic-Traumatological Hospital of He′nan Province (He′nan Provincial Orthopedic Hospital), He′nan Province, Luoyang 471002, China |
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Abstract Necrosis of the femoral head is a common disease in orthopedics. All kinds of animals have their own advantages and disadvantages in loboratory animal modeling. This article summarizes and analyzes the different modeling methods of necrosis of femoral head that has recently appeared at home and abroad. The necrosis of femoral head animal models are divided into a quadruped animal model and a biped animal model, which include rat, rabbit, dog, sheep, pig, and other quadruped animal models, as well as chicken, ostrich, and other biped animal models. In order to discuss the key issues and the direction of improvement to be considered when building animal models. It is hoped that through this review, more scientific modeling methods and more advanced assessment methods will be found, which will provide some references for the selection and establishment of animal models.
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