化浊解毒和胃方对慢性萎缩性胃炎患者VEGF、EGF及Th1/Th2平衡的影响

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Abstract Objective To observe the effect of Huazhuo Jiedu Hewei Recipe on vascular endothelial growth factor (VEGF), epidermal growth factor (EGF) and Th1/Th2 balance in patients with chronic atrophic gastritis with turbid toxin accumulation syndrome. Methods From March 2017 to December 2018, 60 patients with chronic atrophic gastritis diagnosed by gastroscopy in Department of Spleen and Stomach Diseases of Hebei Hospital of Traditional Chinese Medicine were divided into control group and treatment group according to the random number table method, with 30 cases in each group. Control group was treated with Wefuchun, and treatment group was treated with Huazhuo Jiedu Hewei Recipe for 12 weeks. The main symptoms, Th1/Th2 cell level, serum VEGF and EGF levels were compared between two groups. ELISA kit was used to detect the expression of Th1 cytokine IFN-γ and Th2 cytokine serum IL-4, VEGF and EGF. Results Clinical effect of treatment group was better than that of control group, the difference was statistically significant (P < 0.05). After treatment, the scores of stomachache, distention and anorexia in two groups were lower than those before treatment, and scores in treatment group were lower than those in control group, the differences were statistically significant (P < 0.05). There was no significant difference in serum IFN-γ levels between two groups before and after treatment (P > 0.05). After treatment, the level of IL-4 in two groups was higher than that before treatment, and the level of IL-4 in treatment group was higher than that in control group, the difference was statistically significant (P < 0.05). After treatment, the levels of VEGF and EGF in two groups were lower than those before treatment, the differences were statistically significant (P < 0.05). There was no significant difference in levels of VEGF and EGF between two groups (P > 0.05). Conclusion Huazhuo Jiedu Hewei Recipe can not only improve clinical symptoms of chronic atrophic gastritis, but also regulate the balance of Th1/Th2, down-regulate the expression of VEGF and EGF and play a therapeutic role.

Key words： Chronic atrophic gastritis Turbid toxin accumulation syndrome Th1/Th2 Vascular endothelial growth factor Epidermal growth factor

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	LOU Yingying LI Diangui HUO Yongli ZHANG Jinli SUN Runxue LI Yan

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LOU Yingying LI Diangui HUO Yongli ZHANG Jinli SUN Runxue LI Yan. The effect of Huazhuo Jiedu Hewei Recipe on VEGF, EGF and Th1/Th2 balance in patients with chronic atrophic gastritis[J]. 中国医药导报, 2020, 17(4): 143-146.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2020/V17/I4/143

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