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| Effect of combination of Qiangli Loquat Dew and Western medicine on acute exacerbation of chronic bronchitis and its effect on inflammatory factors and quality of life |
| FAN Hongtao HUANG Xiaoping HUANG Xincheng HUANG Wencheng YAN Meihao HONG Yuancheng |
| Department of Respiratory Medicine, the 910th Hospital of Joint Logistic Support Force of the Chinese People′s Liberation Army, Fujian Province, Quanzhou 362000, China |
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Abstract Objective To investigate the effect of combination of Qiangli Loquat Dew with Western medicine on acute exacerbation of chronic bronchitis and its effect on inflammatory factors and quality of life. Methods From February 2017 to February 2019, 98 cases with acute exacerbation of chronic bronchitis received by the 910th Hospital of Joint Logistic Support Force of the Chinese People′s Liberation Army were selected. The patients were randomly divided into the study group and the control group by random numbers method, with 49 cases in each group. The study group was treated with Qiangli Loquat Dew combined with western medicine, while the control group was treated with western medicine. Clinical efficacy, recovery time of clinical symptoms, inflammatory factors, quality of life and adverse reactions of patients were compared between the two groups. Results The total effective rate of the study group after 2 weeks of treatment was higher than that of the control group, and the difference was statistically significant (P ＜ 0.05). The remission time of cough, sputum, fever and lung ralogue symptoms in the study group was shorter than those in the control group, and the differences were statistically significant (all P ＜ 0.05). The serum levels of interleukin-6 (IL-6), IL-8 and tumor necrosis factor-α (TNF-α) of patients in the two groups decreased after 2 weeks of treatment compared with those before treatment, and the study group were lower than those in the control group, the differences were statistically significant (all P ＜ 0.05). The scores of physiological function, physical pain, role physical, general health, social function, energy, emotional function and mental status of patients in the two groups after 2 weeks of treatment were all higher than those before treatment, and the scores of the study group were higher than those in the control group, the differences were statistically significant (all P ＜ 0.05). There was no significant difference of the incidence of adverse reactions of patients between the two groups (P ＞ 0.05). Conclusion In the treatment of acute exacerbation of chronic bronchitis with combination of Qiangli Loquat Dew and Western medicine, the curative effect is definite, the level of inflammatory factors can be effectively improved, and the quality of life of patients can be improved without increasing the incidence of adverse reactions.
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[1] 马正.三伏贴防治慢性支气管炎的疗效观察[J].河北中医，2017，39（12）：1872-1876.
[2] 李岩，郭洋.中医辨证治疗120例慢性支气管炎的临床疗效分析[J].上海医药，2017，38（23）：32-33，54.
[3] 陈勇，谭经福，廖振辉，等.纤维支气管镜肺泡灌洗联合依替米星局部给药治疗支气管扩张并感染的临床疗效[J].疑难病杂志，2018，17（2）：133-136.
[4] 卞艺颖.依替米星联合头孢哌酮/舒巴坦钠治疗老年支气管扩张伴感染的临床疗效分析[J].国际检验医学杂志，2017，38（23）：3356-3358.
[5] Li ZD，Zhang XL，Yi N，et al. Elimination of etimicin in rat kidneys and alterations of its cytotoxicity to tubular epithelial cells [J]. Hum Exp Toxicol，2015，34（5）：479-486.
[6] 关晓娟，吴查青.顶空气相色谱法测定强力枇杷露中薄荷脑的含量[J].中国药房，2016，27（12）：1708-1710.
[7] 陈灏珠.内科学[M].4版.北京：人民卫生出版社，1997.
[8] 杨娟丽，陈璐，杨书芳，等.姑息治疗对晚期肿瘤患者疲乏及生活质量的影响[J].中国老年学杂志，2013，33（4）：886-888.
[9] 国家中医药管理局.中医内科病证诊断疗效标准（试行）[J].成都中医药大学学报，2012，24（2）：F003.
[10] 付英杰.玉屏风散加味结合西医常规疗法治疗慢性支气管炎急性发作临床研究[J].国际中医中药杂志，2017， 39（11）：985-988.
[11] 孙洪伟，刘雪林，宋春艳，等.五拗汤加味联合头孢噻肟钠治疗老年慢性支气管炎急性加重期疗效观察[J].河北医学，2016，22（4）：651-653.
[12] 任庆伟.疏风解毒胶囊联合抗生素治疗慢性支气管炎急性加重期临床观察[J].中国中医急症，2016，25（8）：1571-1573.
[13] Wu Y，Zhao W，Zhu X，et al. Improved liquid chromatography combined with pulsed electrochemical detection for the analysis of etimicin sulfate [J]. J Sep Sci，2016， 39（8）：1471-1479.
[14] 朱婴.桑芩汤治疗慢性支气管炎急性加重期痰热郁肺证的临床疗效评价[D].上海：上海中医药大学，2017.
[15] 袁海英，叶利明.强力枇杷露中齐墩果酸和熊果酸含量测定研究[J].中国测试，2018，44（5）：63-66.
[16] 何江，陈红芳，何荣连，等.强力枇杷露致皮肤变态反应1例[J].医药导报，2019，38（2）：267.
[17] 吴洋，尹晓东，巩伟，等.强力枇杷露质量标准的提高和优化[J].中国药师，2018，21（6）：1119-1123.
[18] 闫翠环，王亚利，张明泉，等.冬病夏治穴位贴敷疗法对慢性支气管炎缓解期患者炎症细胞因子及血清肺表面活性蛋白的影响[J].中医杂志，2016，57（8）：665-668.
[19] 胥陶，曹承刚，张万蓉，等.头孢呋肟联合痰热清对慢性支气管炎患者的疗效及对CRP、TNF-α水平的影响[J].中国医药科学，2018，8（15）：78-80.
[20] 巩晓宇，陆燕萍，邱风邹，等.SPE-HPLC法测定强力枇杷露中盐酸可待因[J].药物评价研究，2017，40（5）：672-674. |
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