高压氧辅助治疗糖尿病周围神经病变临床效果及安全性的meta分析

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Abstract Objective To investigate the clinical effect and safety of hyperbaric oxygen in the adjuvant treatment of diabetic peripheral neuropathy. Methods Cochrane, PubMed, EMBase, CNKI, Wanfang and VIP databases were searched to screen randomized controlled trials of hyperbaric oxygenation in the treatment of diabetic peripheral neuropathy reported from the establishment of the database to April 2019. After literature screening, data extraction and literature quality evaluation by two researchers, the meta-analysis of effective rate and nerve conduction velocity was taken by RevMan 5.2 software. Results A total of 16 articles including 1644 patients were included, including 836 in the experimental group and 808 in the control group. The results of meta-analysis showed that the total effective rate [OR = 7.97, 95%CI (3.95, 16.11), P ＜ 0.000 01, motor nerve conduction velocity [MDmedian nerve = 5.51, 95%CI (3.78, 7.25), P ＜ 0.000 01; MDulnar nerve = 4.49, 95%CI (2.20, 6.78), P = 0.0001; MD peroneal nerve = 5.67, 95%CI (4.18, 7.16), P ＜ 0.000 01; MDtibial nerve = 3.13, 95%CI(1.22, 5.05), P = 0.001]; sensory nerve conduction velocity [MDmedian nerve = 3.25, 95%CI (1.51, 4.99), P = 0.0003; MDulnar nerve = 7.57, 95%CI (2.50, 12.64), P = 0.003; MDperoneal nerve = 4.42, 95%CI (3.70, 5.14), P ＜ 0.000 01; MDtibial nerve = 2.46, 95%CI(0.64, 4.28), P = 0.008] between the experimenttal group and control group, the differences were statistically significant. There were 8 adverse events and side effects in the experimental group, including mild pain, earache, tinnitus, and dizziness, but the injuries were minor, and none in the control group. Conclusion Hyperbaric oxygen-assisted therapy is a safe and effective method , which can improve the therapeutic efficiency of diabetic peripheral neuropathy patients, increase the nerve conduction velocity, reduce adverse events and side effects, and reduce injury.

Key words： Hyperbaric oxygen Diabetic peripheral neuropathy Randomized controlled trial Meta analysis

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	HUANG Chujun1 DING Meizhu1 HUANG Haoyue1 HU Peixin1 WU Jian1 ZHANG Guangqing2

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HUANG Chujun1 DING Meizhu1 HUANG Haoyue1 HU Peixin1 WU Jian1 ZHANG Guangqing2. A meta-analysis of the clinical efficacy and safety of hyperbaric oxygen in the treatment of diabetic peripheral neuropathy[J]. 中国医药导报, 2020, 17(4): 82-88,93.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2020/V17/I4/82

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