初诊肺癌患者血清IL-8、Fractalkine、MIP-3α表达与肺癌临床特征的相关性分析

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Abstract Objective To analyze the correlation of the expression of serum interleukin-8 (IL-8), chemotactic factor (Fractalkine), macrophage inflammatory protein-3α (MIP-3α) and clinical features of lung cancer in patients with newly diagnosed lung cancer. Methods The clinical data of 90 patients with newly diagnosed lung cancer (newly diagnosed lung cancer group, 21 cases of small cell carcinoma and 69 cases of non small cell carcinoma) admitted to Zhongshan Hospital Affiliated to Dalian University from January 2013 to December 2015 and 90 healthy controls with normal results of outpatient physical examination at the same time (healthy group) was analyzed retrospectively. Firstly, the levels of serum IL-8, Fractalkine, MIP-3α between newly diagnosed lung cancer group and healthy group were compared. Secondly, the newly diagnosed lung cancer group was divided into different groups according to Ⅰ+Ⅱ stage and Ⅲ+Ⅳ stage, small cell carcinoma and non-small cell carcinoma, and the levels of serum IL-8, Fractalkine and MIP-3 were compared. At last, Pearson correlation test was used to analyze the relationship among the levels of serum IL-8, Fractalkine and MIP-3 in newly diagnosed lung cancer group. Results ①The levels of IL-8, Fractalkine, MIP-3α in newly diagnosed lung cancer group were higher than those in healthy group (P ＜ 0.01). ②The levels of IL-8, Fractalkine, MIP-3α in Ⅰ+Ⅱ stage group were lower than those in Ⅲ+Ⅳ stage group (P ＜ 0.01). ③The levels of IL-8, Fractalkine, MIP-3α in small cell carcinoma group were higher than those in non-metastasis group, but the differences were not statistically significant (P ＞ 0.05). ④Pearson correlation analysis showed that there was linear correlation of IL-8 and Fractalkine (r = 0.598, P < 0.05), IL-8 and MIP-3α (r = 0.641, P < 0.05), Fractalkine and MIP-3α (r = 0.682, P < 0.05). Conclusion The levels of IL-8, Fractalkine, MIP-3α in patients with newly diagnosed lung cancer are higher than those of healthy persons, and increase with the escalation of the disease, but there are no significant differences between different pathological types. Three indicators are linearly related to each other and can be used for the condition judgment of patients with newly diagnosed lung cancer.

Key words： Lung cancer Interleukin-8 Fractalkine Macrophage inflammatory protein-3α

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	WANG Gang LYU Jinyan WANG Ruoyu ZHAO Jing LIU Ying TANG Rongbin

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WANG Gang LYU Jinyan WANG Ruoyu ZHAO Jing LIU Ying TANG Rongbin. Correlation analysis on the expression of serum IL-8, Fractalkine, MIP-3α and clinical features of lung cancer in patients with newly diagnosed lung cancer[J]. 中国医药导报, 2017, 14(35): 92-95.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2017/V14/I35/92

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