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| Advances in the mechanism of traditional Chinese medicine regulating invasion and metastasis of tumor cells by EMT |
| WANG Qinglan PAN Chen▲ ZHENG Yongfa |
| Ward 2, Department of Oncology, People′s Hospital of Wuhan University, Hubei Province, Wuhan 430060, China
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Abstract Epithelial-mesenchymal transition (EMT) is a key step in the process of differentiation and metastasis of solid cancer. Studies have shown that EMT is involved in a variety of signaling pathways and transcription factors. Therefore, finding the relevant influencing factors of EMT as the therapeutic targets of tumor invasion and metastasis plays an important role in the prevention and treatment of cancer. This paper takes the molecular mechanism of EMT process as the starting point, the development and progression of tumor cell invasion and metastasis regulated by EMT are reviewed. It is beneficial to find therapeutic targets for EMT process, thus providing new therapeutic ideas and directions for malignant tumor development.
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