小儿肺炎患者超敏C反应蛋白、α1酸性糖蛋白、触珠蛋白水平变化及意义

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Abstract Objective To discuss the clinical significance of hypersensitive acute-phase protein (hs-CRP), α1-acid glycoprotein (AAG), haptoglobin (HP) and ceruloplasmin (CP) levels in the surveillance of children with pneumonia. Methods From January to June 2017, 96 children with pediatric pneumonia who were treated in the Second People′s Hospital of Hengshui in Hebei Province (“our hospital” for short), and they were divided into three groups according to the etiology, including 49 cases in bacterial pneumonia group, 27 cases in Mycoplasma pneumonia group, 20 cases in viral pneumonia group. Another 60 healthy children examined in our hospital during the same period were selected as the healthy control group. The hypersensitive C-reactive protein (hs-CRP), alpha-1 acid glycoprotein (AAG), haptoglobin (HP) and ceruloplasmin (CP) of each groups were tested and compared. Results The levels of hs-CRP, AAG and HP in bacterial pneumonia group and Mycoplasma pneumonia group were significantly higher than those in the viral pneumonia group and healthy control group, with statistically significant differences (P < 0.05). The levels of hs-CRP, AAG and HP of children with severe pneumonia from bacterial pneumonia group and Mycoplasma pneumonia group were higher than those of children with mild pneumonia. The levels of hs-CRP, AAG and HP increased with severity of disease, with statistical significance (P < 0.05). The levels of AAG and HP were significant positively correlated with hs-CRP (r = 0.7074, 0.7874, P < 0.01). The level of AAG was significantly positively correlated with HP (r = 0.6882, P < 0.01). There was no significant correlation between the level of CP hs-CRP, AAG and HP (P > 0.05). Conclusion The levels of hs-CRP, AAG and HP in bacterial pneumonia and Mycoplasma pneumonia children were significantly higher than those in the viral pneumonia children and the healthy children. There appeared some well correlation between the levels of hs-CRP, AAG and HP. The three indexes are helpful to a certain extent to identify childhood pneumonia and evaluate the severity caused by pneumonia in children. This provides significance for the clinical treatment of pneumonia in children.

Key words： Pneumonia Hypersensitive acute-phase protein α1-acid glycoprotein Haptoglobin Child

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	NIE Junhong YUAN Lishuang YANG Li ZHAO Guoguang YANG Hualei

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NIE Junhong YUAN Lishuang YANG Li ZHAO Guoguang YANG Hualei. Changes of hs-CRP，AAG and HP level and its clinical significance in children with pneumonia[J]. 中国医药导报, 2020, 17(1): 106-109.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2020/V17/I1/106

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