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| Expression and clinical significance of epidermal growth factor and vascular endothelial growth factor in patients with different phenotypes of bronchial asthma |
| MU Qingshuang Gulixian·Mohemuni Nueramina·Tiliwaer LI Jing |
| Department of Respiratory, the Second Affiliated Hospital of Xinjiang Medical University, Xinjiang Uygur Autonomous Region, Urumqi 830063, China |
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Abstract Objective To investigate the expression and clinical significance of epidermal growth factor (EGF) and vascular endothelial growth factor (VEGF) in patients with different phenotypes of bronchial asthma. Methods A total of 90 patients with acute bronchial asthma admitted to the Second Affiliated Hospital of Xinjiang Medical University from August 2017 to December 2018 were selected as the research objects. The subjects were divided into neutrophil phenotype group (24 cases) and eosinophil phenotype group (66 cases) according to induced type of sputum cell. The serum and sputum levels of EGF and VEGF in the two groups of patients were compared, and the correlation between level of serum eosinophils (EOS) and EGF, VEGF in the eosinophil phenotype group was further analyzed. Results The levels of EGF and VEGF in serum and induced sputum of the patients in the eosinophil phenotype group were significantly higher than those in the neutrophil phenotype group, and the differences were statistically significant (P ＜ 0.05). Serum EOS was positively correlated with serum EGF and VEGF (r = 0.513, 0.397, all P ＜ 0.05), and also positively correlated with the levels of induced sputum EGF and VEGF (r = 0.378, 0.528, all P ＜ 0.05). Conclusion EGF and VEGF in serum and induced sputum of eosinophil phenotype asthma patients are significantly higher than those of neutrophil phenotype bronchial asthma patients, and are correlated with serum EOS levels. The detection of serum EGF and VEGF can simplify the classification and treatment process of bronchial asthma patients, provide help for the treatment of different phenotypes of bronchial asthma.
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