miR-223与妊娠相关疾病的研究进展

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Abstract MicroRNAs (miRNAs) are a class of endogenous non-coding single-stranded RNA molecules of approximately 21-25 bases that have been found in different species and are involved in a variety of biological processes, such as embryonic development, apoptosis, cell division, hematopoiesis, carcinogenesis and viral infection, etc. MicroRNA 223 (miR-223) is a type of miRNA targeting the q12 chromosome of X chromosome. The study found that miR-223 can affect early embryo transfer by inhibiting the expression of leukemia inhibitory factor, insulin-like growth factor. It is abnormally low expressed in peripheral blood and placenta of preeclampsia, involved in the development of preeclampsia. It is low expressed in cardiomyocytes and overexpression in subcutaneous fat of pregnant women with gestational diabetes, regulating the glucose metabolism in the body through different mechanisms. It is highly expressed in pregnant women with premature rupture of membranes. The biological process of the target gene involved in the negative regulation of immune response and anti-inflammatory response, is considered to be closely related to chorioamnionitis. In addition, miR-223 has high expression in children with Down′s syndrome the amount. This article will summarize the research progress of miR-223 expression level and pathological pregnancy such as embryo implantation, pre-eclampsia and gestational diabetes.

Key words： Micro RNA Micro RNA 223 Early embryo implantation Preeclampsia Ggestational diabetes mellitus Premature rupture of membrane Fetal malformation

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	YAO Yanjiao1 DU Nan1 XIE Yanyan1 LU Dan2

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YAO Yanjiao1 DU Nan1 XIE Yanyan1 LU Dan2. Research progress of miR-223 and pregnancy-related diseases[J]. 中国医药导报, 2020, 17(1): 54-57.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2020/V17/I1/54

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