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| Role of androgen receptor splice variants 7 in castration-resistant prostate cancer and its clinical significance |
| ZHANG Ye WANG Lei ZHANG Lu ZHONG Yunping LIU Xiuheng |
| Department of Urology, Renmin Hospital of Wuhan University, Hubei Province, Wuhan 430060, China |
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Abstract Castration-resistant prostate cancer (CRPC) is a prostate cancer that progresses after initial sustained endocrine therapy. The mechanism of CRPC occurrence and development is extremely complicated and has not been fully studied yet, but the continuous activation of androgen receptor (AR) signal is still an important factor. Androgen receptor splice variants 7 (AR-V7) is one of the most important variants of AR. Many studies have shown that it is closely related to the development of CRPC, promoting AR reactivation, tumor growth and metastasis. It plays an important role in the development of drug resistance, and is associated with the sensitivity of endocrine therapy and the overall survival rate. It is a potential evaluation index. In-depth study of the relationship between AR-V7 and CRPC can not only guide the current use of CRPC, it can also provide new ways and directions for the treatment of CRPC.
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