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| The correlation of retinol binding protein 4, lipoprotein (a) level and the severity of coronary artery disease in Uygur elderly patients with acute coronary syndrome |
| Yilihamu·Abulitifu1 Guzili2 Muyesai·Nijiati2 |
1.Graduate School, Xinjiang Medical University, Xinjiang Uygur Autonomous Region, Urumqi 830000, China;
2.Department of Cardiology, the Xinjiang Uygur Autonomous Region People′s Hospital, Xinjiang Uygur Autonomous Region, Urumqi 830000, China |
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Abstract Objective To investigate the relationship between the levels of retinol binding protein 4, lipoprotein (a) and the severity of coronary artery disease in Uygur elderly patients of acute coronary syndrome (ACS). Methods From January 2013 to December 2016, 220 cases of Uygur elderly patients underwent coronary angiography and ≥ 65 years old were retrospectively analyzed and divided into Uygur elderly ACS group (150 cases) and non ACS group (70 cases) according to the clinical diagnostic criteria. Patients in the Uygur elderly ACS group were divided into low-scored groups (45 cases, 0-29), middle-scored group(44 cases, 30-59) and high-scored group(61 cases, ≥60) according to the Gensini score. The retinol binding protein 4 and lipoprotein(a)levels were compared between the Uygur elderly ACS group and non ACS group. The correlation between retinol binding protein 4, lipoprotein (a) and the Gensini score were analyzed. Results The Gensini score, retinol binding protein 4 and lipoprotein(a) in the Uygur elderly ACS group were higher than those of non ACS group. The retinol binding protein 4 and lipoprotein(a) level were increased with the increasing of Gensini score. The Gensini score was positively correlated with the level of retinol binding protein 4 and lipoprotein(a)(r = 0.501、0.704, all P = 0.000). Logistic regression analysis showed that high retinol binding protein 4 and lipoprotein (a) levels were the independent risk factors of high Gensini scores in Uygur elderly patients. Conclusion The elevated levels of retinol binding protein 4 and lipoprotein(a) are associated with the severity of coronary artery disease and those are risk factors for the aggravation of coronary artery disease. In clinical work, the indicators of retinol binding protein 4 and lipoprotein (a) should be detected in Uygur elderly patients of ACS and early prevention should be carried out and that have important clinical significances for Uygur elderly patients of ACS.
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