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| Clinical effect of Total Glycosides of Paeony Capsules combined with Hydroxychloroquine Sulfate in the treatment of Sjogren′s syndrome |
| LU Daiguo WANG Luyao WANG Guihong ZUO Zhengcai |
| Department of Rheumatology and Immunology, Anqing Hospital Affiliated to Anhui Medical University, Anhui Province, Anqing 246000, China |
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Abstract Objective To investigate clinical effect of Total Glucosides of Paeony Capsules combined with Hydroxychloroquine Sulfate in the treatment of Sjogren′s syndrome (SS). Methods One hundred SS patients admitted to Anqing Hospital Affiliated to Anhui Medical University from September 2015 to March 2019 were divided into control group (50 cases) and observation group (50 cases) according to random number table method. Control group was treated with Hydroxychloroquine Sulfate, while observation group was treated with Total Glucosides of Paeony Capsules combined with Hydroxychloroquine Sulfate. Both groups were treated for 3 months. Clinical effect of two groups was evaluated and compared. The dry mouth score, dry eye score, fever score, joint pain score, erythrocyte sedimentation rate (ESR), immunoglobulin G (IgG) and C reactive protein (CRP) level were compared between two groups before and after treatment. The occurrence of adverse reactions during the treatment was recorded. Results Total clinical effective rate of observation group was significantly higher than that of control group, there was a significant difference between two groups (P < 0.05). After treatment, the scores of dry mouth, dry eye, fever and joint pain in two groups were significantly lower than those before treatment (P < 0.05), while scores of dry mouth, dry eye, fever and joint pain in observation group were significantly lower than those in control group (P < 0.05). ESR, IgG and CRP in two groups were significantly lower than those before treatment (P < 0.05), while ESR, IgG and CRP in observation group were significantly lower than those in control group (P < 0.05). During the treatment period, there was no significant difference between two groups (P > 0.05). Conclusion Total Glucosides of Paeony Capsules combined with Hydroxychloroquine Sulfate in the treatment of SS has significant clinical efficacy, which can significantly improve clinical symptoms, and has good safety.
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