|
|
|
| Cognition investigation of GnRH-a in combination with add-back therapy in ethnic minority patients with uterine leiomyoma in Xinjiang District and discussion the new model of health education |
| ZHU Ye1 MI Juanni2 ZHU Hongyan1▲ HE Yan1 |
| 1．Ward 3, Department of Gynecology, the First Affiliated Hospital of Xinjiang Medical University, Xinjiang Uygur Autonomous Region， Urumqi 830054, China; 2.VIP of Internal Medicine, the First Affiliated Hospital of Xinjiang Medical University，Xinjiang Uygur Autonomous Region， Urumqi 830054, China |
|
|
|
Abstract Objective To survey cognition level of gonadotrophin releasing hormone agonist (GnRH-a) in combination with add-back therapy in ethnic minority patients with uterine leiomyoma in Xinjiang District and discuss the new model of health education. Methods From January 2017 to December 2018, 80 ethnic minority cases with uterine leiomyoma received GnRH-a combination with add-back therapy in the First Affiliated Hospital of Xinjiang Medical University were collected as observational objects. According to the random number table method, they were divided into control group and observation group, with 40 cases in each group. Control group was given conventional health education, while observation group was given multi-dimensional medical care integration mode health education. Cognitive scores of GnRH-a combined with add-back therapy, levels of hormone, adverse reactions and levels of bone mineral density (BMD) were compared between two groups. Results Before health education, there were no statistically significant differences in the cognitive scores of GnRH-a combination with add-back therapy between two groups (P > 0.05). After health education, the cognitive scores of GnRH-a combination with add-back therapy in both groups were increased, and observation group was higher than control group, with statistically significant differences (P < 0.05). The levels of follicule-stimulating hormone (FSH), lutropin (LH), estradiol (E2) was decreased in both groups, and the levels of FSH, LH in observation group was lower than those in control group, while the level of E2 in observation group was higher than that in control group, with statistically significant differences (all P < 0.05). The BMD levels of 1-4 lumbar spine (L1-L4) and femoral head in both groups were decreased, and observation group was higher than control group, and the differences were statistically significant (all P < 0.05). The incidence of adverse reactions in observation group were lower than that in control group, and the differences were statistically significants (P < 0.05). Conclusion Ethnic minority patients with uterine leiomyoma in Xinjiang District has low level of cognition of GnRH-a combined with add-back therapy. And multi-dimensional medical care integration mode health education can increase cognition level, improve levels of sex hormones, reduce incidences of adverse reactions and has less influences on bone loss.
|
|
|
|
|
|
[1] Packenham JP，du Manoir S，Schrock E，et al. Analysis of genetic alterations in uterine leiomyomas and leiomyosarcomas by comparative genomic hybridization [J]. Mol Carcinog，2015，19（4）：273-279.
[2] 褚达明，欧阳玲.子宫肌瘤剔除术联合GnRH-a治疗弥漫性子宫平滑肌瘤病六例[J].实用肿瘤杂志，2017，32（2）：147-151.
[3] 刘志宇，李慧.子宫肌瘤治疗新进展[J].现代中西医结合杂志，2016，25（29）：3304-3306.
[4] 周怀君.子宫肌瘤的诊断[J].中国计划生育和妇产科，2012，4（3）：34-37.
[5] Yang Q，Mas A，Diamond MP，et al. The mechanism and function of epigenetics in uterine leiomyoma development [J]. Reprod Sci，2016，23（2）：163-175.
[6] 叶青，史晶晶，郭莹.促性腺激素释放激素激动剂（GnRH-a）联合腹腔镜治疗巨大子宫肌瘤的疗效观察[J].实用妇科内分泌电子杂志，2016，3（2）：145-147.
[7] 米合日尼沙·买买提，王琳，韩丽丽.子宫内膜异位症保守手术后GnRH-a联合戊酸雌二醇反向添加疗法的效果及其对血清VEGF、CA125、IL-6、TNF-α的影响[J].中国妇幼保健，2018，33（4）：783-787.
[8] 王颖.GnRH-a对米非司酮治疗子宫肌瘤患者血清FSH、E_2、P和临床效果的影响[J].放射免疫学杂志，2013， 26（5）：575-576.
[9] 张慧英.子宫肌瘤药物治疗进展[J].国际妇产科学杂志，2013，40（4）：339-342.
[10] 王琪娜，阮海玲，崔玲，等.健康宣教对急性心肌梗死康复出院老年患者生活方式的影响[J].中国医药导报，2016，13（1）：163-167.
[11] 朱怀燕.个性化定制健康宣教方案提高结肠造口患者自我护理能力的研究[J].实用临床医药杂志，2015，19（4）：73-75.
[12] 余珊，王波.糖尿病健康教育研究进展[J].昆明医科大学学报，2018，39（4）：130-134.
[13] 徐国仙.医护协作早产儿护理门诊的工作模式探讨[J].护理实践与研究，2017，14（18）：101-103.
[14] 蒋艳，周玉萍，彭小华，等.医护合作模式在神经综合病房管理中的应用[J].护理研究，2013，27（3）：273-274.
[15] 崔银杰，张超，贾爱玲，等.医护合作责任制护理模式对社区老年2型糖尿病患者的管理效果研究[J].实用临床医药杂志，2017，21（16）：145-147.
[16] 马慧珍，李倩，何慧娟，等.PICC置管患者医护协同全程管理效果探讨[J].护理学杂志，2017，32（5）：45-47.
[17] 梁丽芬.协同护理模式应用于经皮肾穿刺活检术患者中的效果评价[J].中国药物与临床，2018，8（8）：176-178.
[18] 于治芳，张利萍.协同护理联合持续健康宣教对卵巢癌患者术后自我管理及生活质量的影响[J].中国医药导报，2019，16（2）：139-142.
[19] 王新侠，徐贵红，徐桂梅，等.多维健康教育模式在孕产妇妊娠及产后盆底肌锻炼中的运用[J].临床与病理杂志，2017，（4）：707-712.
[20] 宋阳，甄玉花，关永格，等.大鼠荷子宫肌瘤组织移植瘤模型的建立[J].中国实验动物学报，2018，26（1）：91-94.
[21] 王欣.协同护理模式对老年糖尿病患者身心状态的影响[J].安徽医药，2018，22（12）：2407-2409. |
|
|
|
