新生儿肠外营养相关性胆汁淤积的研究进展

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Abstract With the widespread use of parenteral nutrition in newborns, parenteral nutrition associated cholestasis (PNAC) has become one of the common complications in neonates, especially preterm infants. The disease often causes hepatocyte steatosis and cholestasis of the child, leads to biliary cirrhosis, which can cause liver failure and even death. Therefore, the disease should be highly valued by neonatal physicians. Due to the pathogenesis of PNAC is still unclear and controversial, this paper studys and summarizes a large number of recent literatures on PNAC, and found that PNAC is associated with premature birth and low birth weight, prolonged fasting, infection, parenteral nutrition application time, nutritional imbalance, and genetic factors. This article will review the known pathogenesis, diagnosis, treatment and new research progress.

Key words： Neonate Premature infant Parenteral nutritional associated cholestasis Parenteral nutrition

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	LYU Meng1 LIU Xiuxiang1
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LYU Meng1 LIU Xiuxiang1,2. Research progress on parenteral nutrition associated cholestasis in neonates[J]. 中国医药导报, 2019, 16(36): 46-49.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2019/V16/I36/46

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