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| Advance in the immunological detection technologies research of serum protein biomarkers |
| ZHANG Xue CHEN Yanjiao CHENG Mi MAO Junxia SHI Yanglin YANG Yongqing XU Yudong |
| Shanghai University of Traditional Chinese Medicine, Shanghai Research Institute of Acupuncture & Meridian, Shanghai 200030, China |
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Abstract Serum protein biomarkers are important molecular markers for labeling changes in tissues, organs and cell functions during disease, which have important application value in disease diagnosis and treatment. The development of immunological assays such as enzymatic chemiluminescence immunoassays, multiplex fluorescence immunoassays, and electrochemiluminescence immunoassays provides various methods for serum protein biomarkers detection. In this review, the technical characteristics, application research, advantages and disadvantages of the commonly used serum protein biomarker detection methods are analyzed and compared in order to provide useful reference for researchers.
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