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Effect of Progesterone combined with Phloroglucin on the expression of SOCS3 and perinatal outcome in threatened abortion |
ZHAO Junda GUO Chunfeng MA Junqi▲ |
Department of Gynecology, the First Affiliated Hospital, Xinjiang Medical University, Xinjiang Uygur Autonomous Region, Urumqi 830011, China |
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Abstract objective To explore the effect of Progesterone combined with Phloroglucin on the expression suppressors of cytokine signaling 3 (SOCS3) and perinatal outcome in threatened abortion. Methods From June 2015 to June 2017, 94 cases with threatened abortion treated in Department of Gynecology, the First Affiliated Hospital, Xinjiang Medical University were seleted. According to random number table method, they were divided into the observation group and the control group, with 47 cases in each group. The control group was treated with Progesterone, while the observation group was added with Phloroglucin on the basis of the control group. The clinical treatment effect and the expression levels of SOCS3 of two groups were compared. The incidence of gestational hypertension, placental abruption, placental previa, placental premature rupture, gestational diabetes, neonatal malformation, full-term low birth weight, premature birth, neonatal death, and 1 min Apgar score were also recorded. Results The clinical treatment effect of the observation group was higher than that of the control group, and the difference was statistically significant (P < 0.05). One week after treatment, the mRNA and protein levels of SOCS3 in the observation group were significantly higher than those in the control group, with the differences were statistically significant(P < 0.05). There were no significant differences in the incidence of gestational hypertension, placental abruption, placental previa, placental premature rupture and gestational diabetes between the two groups (P > 0.05). There were no statistically significant differences between the two groups in neonatal malformation, full-term low birth weight, premature birth, neonatal death, and 1 min Apgar score (P > 0.05). Conclusion Progesterone combined with Phloroglucin in the treatment of threatened abortion clinical effect is significant, which can significantly improve the patients′ SOCS3 level and no adverse perinatal outcomes.
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