宫颈癌组织中miR-216b与FOXM1表达及与临床病理特征的关系

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Abstract Objective To study the expression of micro RNA (miR)-216b and forkhead box protein M1 (FOXM1) in cervical cancer and its relationship with clinicopathological features. Methods From March 2016 to March 2019, 84 cases with cervical cancer diagnosed and treated in the Central Hospital of Wuhan, Tongji Medical College of Huazhong University of Science and Technology were selected as case group. In the same period, 40 cases with cervical intraepithelial neoplasia (CIN) were selected as CIN group, and 40 cases with benign uterine lesions were used as control group. The expressions of miR-216b and FOXM1 in each group were detected by real-time fluorescent quantitative PCR. Its relationship with clinicopathological features were compared and the correlation was analyzed. Results The expression of miR-126b in case group was significantly lower than that in CIN group and control group, while the FOXM1 in case group was significantly higher than that in CIN group and control group, and the differences were statistically significant (all P < 0.05). The expression of miR-126b and FOXM1 were correlated with FIGO stage, degree of tumor differentiation and depth of infiltration, but not with age, pathological type, lymph node metastasis and human papillomavirus (HPV) 16/18 infection. The expression of miR-126b was negatively correlated with the expression of FOXM1 (r = -0.694, P = 0.001). Conclusion MiR-126b and FOXM1 are abnormally expressed in cervical cancer tissues. Both of them are involved in the occurrence and development of cervical cancer, and may become new tumor markers for cervical cancer diagnosis, treatment and prognosis evaluation.

Key words： Cervical cancer MiR-216b Forkhead box protein M1 Infiltration

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	WANG Mengyi LU Hongda CHEN Li LEI Zhang

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WANG Mengyi LU Hongda CHEN Li LEI Zhang. Expression of miR-216b and FOXM1 in cervical cancer and its relationship with clinicopathological features[J]. 中国医药导报, 2019, 16(35): 86-89.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2019/V16/I35/86

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