血清miR-181b、miR-210表达与妊娠期高血压疾病患者炎性因子的关系

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Abstract Objective To explore the expression of serum microRNA-181b (miR-181b), miR-210 in patients with hypertensive disorder of pregnancy (HDP) and the relationship with inflammatory factors. Methods From January 2016 to January 2018, 183 cases with HDP admitted to Cangzhou People′s Hospital were collected as case group. According to the severity of the disease, they were divided into hypertensive pregnancy subgroup (n = 51), mild preeclampsia subgroup (n = 79) and severe preeclampsia subgroup (n = 53). At the same time, 55 cases with healthy single pregnant women were randomly selected as control group. The relative expression of serum miR-181b, miR-210 and serum inflammatory factors such as interleukin (IL)-1β, IL-6, IL-10, IL-17 and tumor necrosis factor-α (TNF-α) in each group were detected and compared. Pearson accumalates correlation analysis was used to analyze the correlation between serum miR-181b, miR-210 and IL-1β, IL-6, IL-17, TNF-α and IL-10. Results The serum miR-181b and miR-210 and IL-1β, IL-6, IL-17, TNF-α in case group were higher than those in control group, and IL-10 was lower than that in control group, and the differences were statistically significant (all P < 0.05). Comparison of serum miR-181b, miR-210 and IL-1β, IL-6, IL-17, TNF-α in different HDP subgroups showed statistically significant differences (all P < 0.05). MiR-181b, miR-210 and IL-1β, IL-6, IL-17, TNF-α expression in mild preeclampsia subgroup were higher than those in hypertensive pregnancy subgroup, and IL-10 was lower than that in hypertensive pregnancy subgroup, and the differences were statistically significant (all P < 0.05). miR-181b, miR-210 and IL-1β, IL-6, IL-17, TNF-α expression in severe preeclampsia subgroup were higher than those in mild preeclampsia subgroup, and IL-10 was lower than that in mild preeclampsia subgroup, and the differences were statistically significant (all P < 0.05). Pearson accumulates correlation analysis showed that serum miR-181b in HDP patients was positively correlated with IL-1β (r = 0.722, P < 0.01), IL-6 (r = 0.759, P < 0.01), IL-17 (r = 0.713, P < 0.01) and TNF-α (r = 0.736, P < 0.01), and negatively correlated with IL-10 (r = -0.781, P < 0.01). miR-210 in HDP patients was positively correlated with IL-1β (r = 0.765, P < 0.01), IL-6 (r = 0.793, P < 0.01), IL-17 (r = 0.738, P < 0.01) and TNF-α (r = 0.772, P < 0.01), and negatively correlated with IL-10 (r = -0.745, P < 0.01). Conclusion The up-regulation of serum miR-181b and miR-210 mediates the occurrence and development of HDP, which also are closely related to the severity of the disease and the intensity of inflammation.

Key words： MicroRNA-181b MicroRNA-210 Hypertensive disorder of pregnancy Inflammatory factors

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	REN Na JI Jinghuan

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REN Na JI Jinghuan. The relationship between the expression of serum miR181b, miR-210 and inflammatory factors in patients with hypertensive disorder of pregnancy[J]. 中国医药导报, 2019, 16(35): 82-85,89.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2019/V16/I35/82

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