半夏白术天麻汤联合氯吡格雷治疗急性缺血性脑卒中的临床效果

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Abstract Objective To observe the clinical effect of Banxia Baizhu Tianma Decoction combined with Clopidogrel in the treatment of acute ischemic stroke. Methods A total of 183 patients with acute ischemic stroke admitted to Ankang Hospital of Traditional Chinese Medicine from March 2016 to March 2019 were divided into control group (91 cases Clopidogrel) and research group (92 cases, Banxi Baizhu Tianma Decoction combined with Clopidogrel) according to the random number table method. The clinical efficacy, national institutes of health stroke scale (NIHSS), modified Barthel index (mBI) and serum related indicators were compared between the two groups, and adverse reactions were recorded. Results After treatment, the total clinical effective rate of the study group was higher than that of the control group (P ＜ 0.05). After treatment, the NIHSS, soluble P-selectin and matrix metalloproteinase-9 decreased in both groups, and the study group was lower than the control group. mBI score, vascular endothelial growth factor and brain-derived neuronutrition increased in both groups, and the study group was higher than the control group (P ＜ 0.05). There was no difference in the incidence of adverse reactions between the two groups (P > 0.05). Conclusion Conventional Clopidogrel combined with Banxia Baizhu Tianma Decoction in the treatment of acute ischemic stroke can effectively improve the daily activities of patients, alleviate the degree of neurological impairment, improve the level of relevant serum indicators, and do not increase the incidence of adverse reactions.

Key words： Banxia Baizhu Tianma Decoction Clopidogrel Acute ischemic stroke Clinical effect

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	TANG Yong CHEN Liang ZHANG Chao CHEN Wenbo LI Jin WANG Xiaoling

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TANG Yong CHEN Liang ZHANG Chao CHEN Wenbo LI Jin WANG Xiaoling. Clinical effect of Banxia Baizhu Tianma Decoction combined with Clopidogrel in the treatment of acute ischemic stroke[J]. 中国医药导报, 2019, 16(35): 78-81.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2019/V16/I35/78

[1] 陈增力，刘萍，于文.补肾活血方配合电针治疗缺血性脑卒中疗效观察[J].国际中医中药杂志，2014，28（11）：1031-1033.
[2] Bergmeijer TO，van Oevelen M，Janssen PWA，et al. Safety of Ticagrelor Compared to Clopidogrel after Prehospital Initiation of Treatment [J]. TH Open，2018，2（4）：e357-e368.
[3] 张茂，冯奇桃，陈丽丽，等.血栓通联合脑得生浓缩丸治疗急性缺血性脑卒中的临床研究[J].中西医结合心脑血管病杂志，2017，15（13）：1638-1641.
[4] 张瑛，戴启荷.半夏白术天麻汤加减联合依达拉奉治疗急性缺血性脑卒中效果观察[J].现代中西医结合杂志，2016，25（16）：1763-1765.
[5] 中华医学会神经病学分会脑血管病学组急性缺血性脑卒中诊治指南撰写组.中国急性缺血性脑卒中诊治指南2010[J].中华神经科杂志，2010，2（2）：50-59.
[6] 郑筱萸.中药新药临床研究指导原则.（试行）[Ｍ].北京：中国医药科技出版社，2002，48.
[7] 陈应柱，刘刚，杨璞，等.不同TOAST亚型老年急性脑梗死患者血清髓鞘碱性蛋白水平变化及其临床意义[J].中国急救医学，2012，32（4）：291-294.
[8] 顾琦，沈光宇，孙莹，等.脑卒中患者专科康复后离院时日常生活活动能力依赖程度分析[J].中国康复医学杂志，2018，33（11）：1311-1313.
[9] Sarkar RN，Das CK，Bhattacharjee U，et al. Platelet Indices as a Marker of Severity in Non-diabetic NonHypertensive Acute Ischemic StrokePatients [J]. J Assoc Physicians India，2018，66（7）：40-42.
[10] 杨成，钱捷，唐迅，等.阿司匹林单独或与氯吡格雷联合用药治疗缺血性脑卒中及短暂性脑缺血发作疗效和不良反应的Meta分析[J].中华流行病学杂志，2015，36（12）：430-1435.
[11] 陈琳，王志强，肖莉，等.脑卒中相关症状与院前延迟的相关性研究[J].成都医学院学报，2018，13（4）：439-444.
[12] 贾爱明，谭婧，胡文梅，等.缺血性脑卒中复发的体质因素及中医诱因[J].中国老年学杂志，2014，34（9）：2435-2437
[13] 刘芳，周德生，贺海霞，等.缺血性脑卒中患者复发与其中医体质的相关性研究[J].世界中医药，2017，12.（5）：1014-1017.
[14] 赵心想，苑海霞，宋彩霞，等.半夏白术天麻汤治疗缺血性脑卒中急性期患者的临床疗效及其对凝血功能、脑血流动力学的影响[J].实用心脑肺血管病杂志，2019， 35（4）：59-63
[15] Patel S，Arya V，Saraf A，et al. Aspirin and Clopidogrel Resistance in Indian Patients with Ischemic Stroke and its Associations with Gene Polymorphisms: A Pilot Study [J]. Ann Indian Acad Neurol，2019，22（2）：147-152.
[16] 谢红，陈亮.针灸联合半夏白术天麻汤治疗老年风痰阻络型脑梗死及对患者认知功能影响[J].陕西中医，2016， 37（10）：1408-1409.
[17] 赵心想，苑海霞，宋彩霞，等.半夏白术天麻汤治疗缺血性脑卒中急性期患者的临床疗效及其对凝血功能、脑血流动力学的影响[J].实用心脑肺血管病杂志，2019， 27（4）：59-63.
[18] Tejeda GS，Esteban-Ortega GM，San Antonio E，et al. Prevention of excitotoxicity-induced processing of BDNF receptor TrkB-FL leads to stroke neuroprotection [J]. EMBO Mol Med，2019，11（7）：e9950.
[19] 张鹏，杨海明，马存凯，等.缺血性脑卒中患者血清基质金属蛋白酶-2、-9与chemerin表达及相关性[J].中国老年学杂志，2018，38（11）：2607-2608.
[20] Setyopranoto I，Sadewa AH，Wibowo S，et al. Comparison of Mean VEGF-A Expression Between Acute Ischemic Stroke Patients and Non-Ischemic Stroke Subjects [J]. Open Access Maced J Med Sci，2019，7（5）：747-751.
[21] 朱红霞，张国柱.半夏白术天麻汤治疗脑卒中后眩晕疗效观察[J].安徽中医药大学学报，2018，37（5）：22-24.
[22] 陈国宁，林泽辉，杜永明，等.丹参川芎嗪注射液对缺血性脑卒中患者同型半胱氨酸、高敏C反应蛋白和血脂水平的影响及疗效观察[J].中国医药导报，2018，15（1）：76-79.
[23] 费明峰，赵园园，吴玉泉，等.丹参多酚酸盐联合奥拉西坦治疗高龄腔隙性脑梗死临床疗效观察[J].中国现代医生，2017，55（30）：11-14.