心脏瓣膜外科术后口服华法林抗凝治疗监测策略探讨

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Abstract Objective To explore the monitoring strategy of Warfarin anticoagulant index prothrombin time-international normalized ratio (PT-INR) in patients after cardiac valve surgery, and to find a suitable follow-up monitoring method for patients after valvular surgery. Methods One hundred and seven patients undergoing cardiac valve surgery and requiring oral Warfarin anticoagulant therapy in Adult Area Two of Cardiac Surgery of Guangdong Provincial People′s Hospital were selected in this study from January to March 2019. According to the different anticoagulant monitoring methods, the same patient was divided into two groups: control group was taken Sodium Citrate intravenous anticoagulant and sent to the hospital laboratory, and the PT-INR results were obtained by using STAGO-E monitoring instrument produced by Sitagao Company of France, and two drops of whole blood from fingertip endings were taken from experimental group, and PT-INR results were obtained by Shenzhen qLabsPT-INR (Q1/Q3 model) coagulation detector. The correlation and deviation analysis of PT-INR between two groups of anticoagulant monitoring results were carried out, and the advantages and disadvantages of the two monitoring methods were discussed. Results There was a good correlation between the two blood coagulation monitoring instruments, the correlation coefficient R was more than 0.9, and the deviation of the results was small. It was consistent with INR (1.5-2.5) in the anticoagulation window after mechanical valvular replacement, and had good consistency and stability. The portable Shenzhen qLabs coagulation detector was easy to accept because of its convenient operation, quick result and obvious economic effect. Conclusion The portable Shenzhen qLabs blood coagulation detector has a good correlation with the large-scale instruments in the hospital, and is especially suitable for patients who are required to be treated within the treatment window after cardiac mechanical valve replacement.

Key words： Anticoagulation monitoring Coagulation analyzer Follow-up management model Cardiac valve surgery Self-detection

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	PENG Xiaopeng1
	2 ZHOU Chengbin1 HUANG Jinsong1▲ WU Min1

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PENG Xiaopeng1,2 ZHOU Chengbin1 HUANG Jinsong1▲ WU Min1. Exploration monitoring strategy of oral Warfarin anticoagulation therapy after cardiac valve surgery[J]. 中国医药导报, 2019, 16(35): 52-56.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2019/V16/I35/52

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