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| Correlation between glycolipid metabolic abnormalities and insulin resistance in patients with phlegm-dampness polycystic ovary syndrome |
| TIAN Xiaoying1 XU Fang2▲ CHEN Haobo1 MENG Xiaoyu2 HOU Lihui2 |
1.Department of Traditional Chinese Medicine Gynecology, Wenzhou Integrated Traditional Chinese and Western Medicine Hospital, Zhejiang Province, Wenzhou 325000, China;
2.Department of Gynaecology and Obstetrics, the First Affiliated Hospital of Heilongjiang University of Chinese Medicine, Heilongjiang Province, Harbin 150040, China |
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Abstract Objective To investigate the relationship between abnormal glucose and lipid metabolism and insulin resistance (IR) in patients with phlegm-dampness polycystic ovary syndrome (PCOS). Methods A total of 118 patients with phlegm-dampness PCOS were selected from the First Affiliated Hospital of Heilongjiang University of Chinese Medicine and Gynecological Clinic of Wenzhou Integrated Hospital of Traditional Chinese and Western Medicine from November 2014 to September 2018. According to IR index > 2.69, they were divided into PCOS+IR group of 67 cases and PCOS+NIR group of 51 cases. Age, weight, sex hormones, OGTT, insulin release test and blood lipid were compared between two groups. Results There was no significant difference in age, BMI and WHR between two groups （P > 0.05）. The levels of LH/FSH and SHBG in PCOS+IR group were lower than those in PCOS+NIR group, the levels of AND and FAI in PCOS+IR group were higher than those in PCOS+NIR group (P < 0.05). The levels of HDL and ApoA in PCOS+IR group were lower than those in PCOS+NIR group (P < 0.05). FPG and 30, 60, 120 min glucose levels and GAUC in PCOS+IR group were higher than those in PCOS+NIR group, the differences were statistically significant (P < 0.05). FINS and 30, 60, 120, 180 min insulin levels and IAUC in PCOS+IR group were higher than those in PCOS+NIR group, the differences were statistically significant (P < 0.05). Conclusion PCOS of phlegm-dampness type is abdominal obesity. Patients with PCOS and IR show higher androgen level, and IR aggravate the abnormal glucose and lipid metabolism.
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