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| Research progress of surface-modified sugar nanoparticles active targeting on tumors |
| ZHANG Changmei CHEN Zhong TANG Xuefeng LI Minghui |
| Pharmaceutical Preparation Teaching and Research Section, Daqing Campus of Harbin Medical University, Heilongjiang Province, Daqing 163319, China |
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Abstract The surface of nano preparation modified by carbohydrate compounds can achieve tumor targeted drug delivery and enhance the anti-tumor effect of drugs. In this paper, tumor targeting effects of nanocentric drugs designed with different types of sugar compounds as transport substrates are reviewed. Meanwhile, based on Warburing effect and glucose transport process, the anti-tumor mechanism of glycolide-modified nanodrugs is studied. The glucose-ligand modified nanomaterials can effectively control or utilize the role of glucose transporters in Warburg effect, providing theoretical basis for the design of more effective and reasonable anti-tumor targeted drugs.
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