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| Analysis of discharge medication guidances and gender differences for patients with severe mental disorders |
| PAN Li1 CHENG Jun1 SHENG Hui2 |
1.Department of Psychiatry, Wuhan Excellent Hospital, Hubei Province, Wuhan 430023, China;
2.Department of Gynecology, Wuhan Fourth Hospital, Hubei Province, Wuhan 430023, China |
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Abstract Objective To explore the clinical characteristics and gender differences of discharge medication guidance in discharge information sheet of patients with severe mental disorders. Methods The medication guidance on the discharge information sheet of patients with severe mental disorders filled out by psychiatric practitioners in Wuhan Excellent Hospital (“our hospital” for short) in 2018 was taken as the research object. There were a total of 399 discharge information sheets, including 257 male patient discharge information sheets and 142 female patient discharge information sheets. According to the discharge medication guidance filled in by psychiatrists, we conducted a clinical study analysis including gender differences with the antipsychotic drugs used as the main line in this research. Results In 2018, risperidone was the antipsychotic drug with the highest usage rate among patients with severe mental disorders in our hospital, followed by Olanzapine, Clozapine, Aripiprazole, Quetiapine and Sulfamethylate successively. The usage rate of typical antipsychotic drugs was relatively low (accounting for 4.91% of the total number). The proportion of male patients with severe mental disorders receiving antipsychotic treatments with Risperidone and Clozapine was significantly higher than that of female patients (P ＜ 0.01 or P ＜ 0.05). Among the patients receiving oral Risperidone for antipsychotic treatment, there was no statistically significant difference in the dose between male and female patients (0.05 ＜ P ＜ 0.10). The proportion of female patients taking Olanzapine, Aripiprazole, Amisulpiride and Ziprasidone was higher than that of male patients, the differences were statistically significant (P ＜ 0.01 or P ＜ 0.05). The proportion of female patients with severe mental disorders using Aripiprazole for antipsychotic treatment and the mean dose at treatment were higher than those of male patients (all P ＜ 0.05). The proportion of female patients who received Amsulpiride as a major antipsychotic drug was higher than that of male patients (P ＜ 0.01), and the average dose of amsulpiride for female patients in the study was also higher than that for male patients (P ＜ 0.05). There were no statistically significant differences between male and female patients in the use of quetiapine tablets, paliprazone, typical antipsychotics, as well as mood stabilizers, sedative hypnotics, and antidepressants (P ＞ 0.05). Conclusion Atypical antipsychotics are currently the first-line treatment for patients with severe mental disorders. There is a gender difference in the choice of new antipsychotics for patients with severe mental disorders. There is gender difference in the average dose of some antipsychotic. But there is no gender difference in the treatment of emotional stabilizers, sedative hypnotics, and antidepressants.
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