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| Clinical effect of Lipoic Acid combined with non-invasive ventilator in treatment of obstructive sleep apnea hypopnea syndrome |
| HAO Weihua1 LIU Yanjie1 JIANG Fang1 CAI Shijie1 YANG Huijun2 |
1.Ward One, Department of Geriatrics, Shijiazhuang First Hospital, Hebei Province, Shijiazhuang 050011, China;
2.the Second Department of Respiration, Shijiazhuang First Hospital, Hebei Province, Shijiazhuang 050011, China |
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Abstract Objective To explore the clinical efficacy and safty of Lipoic Acid combined with non-invasive ventilator in treatment of obstructive sleep apnea hypopnea syndrome (OSAHS). Methods From January 2016 to June 2018, 80 cases with OSAHS admitted to Shijiazhuang First Hospital were selected. According to the random number table method, they were divided into the control group (40 cases) and the observasion group (40 cases). The control group was treated with non-invasive ventilator, and the observasion group was treated with Lipoic Acid combined with non-invasive ventilator. Both groups were continuously treated for 12 weeks. Clinical efficacy was evaluated after treatment. The Epworth somnolence scale (ESS) scores, athens insomnia scale scores, apnea hypopnea index (AHI), blood oxygen saturation (SpO2), medial blood oxygen saturation (MSpO2), and levels of serum malondialdehyde (MDA), superoxide dismutase (SOD) and hypoxia inducible factor-1α (HIF-1α) were compared before and after treatment. The occurrence of adverse reactions were recorded. Results The total clinical effective rate of the observasion group was significantly higher than that of the control group, the difference was statistically significant (P < 0.05). The ESS scores, athens insomnia scale scores of the observasion group after treatment were significantly lower than those of the control group, the differences were statistically significant (all P < 0.05). AHI of the observasion group after treatment was significantly lower than that of the control group, SpO2 and MSpO2 of the observasion group after treatment were significantly higher than those of the control group, the differences were statistically significant (all P < 0.05). The levels of MDA and HIF-1α of the observasion group after treatment were significantly lower than those of the control group, the level of SOD of the observasion group after treatment were significantly higher than that of the control group, the differences were statistically significant (all P < 0.05). During treatment, there was no serious adverse reaction in both two groups. Conclusion Lipoic Acid combined with non-invasive ventilator has significant clinical efficacy in treatment of OSAHS. It can improve the sleep breathing status and blood oxygen saturation, regulate the indicators of oxidative stress response, and has good safety.
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