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| The role of breast milk combined with breast milk fortifier in improving the growth and development of very low birth weight premature infants |
| XU Jingyi ZHOU Wen CHEN Lan LUO Rui LIU Ling |
| Department of Neonatology, Maternal and Child Health Hospital of Guiyang City, Guizhou Province, Guiyang 550001, China |
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Abstract Objective To explore the role of breast milk combined with breast milk fortifier in improving the growth and development of premature infants with very low body weight （VLBW). Methods From January 2016 to December 2017, 200 cases of VLBW premature infants born and completed in the Department of Obstetrics and Gynecology, Guiyang City Maternal and Child Health Hospital of Guizhou Province were selected as subjects, and they were divided into breast milk group and breast milk enhancer group according to feeding methods, 100 cases in each group. Growth data and growth deviation of preterm infants between the two groups at 1, 2 months and 3 months were compared. The incidence of feeding intolerance, complications, and infant neurological international battery (INFANIB) scores were compared between the two groups. Results Compared with the premature infants in the breast milk group, the age-specific body weight Z score, age-head circumference Z-score, age-specific body length Z score, body length and body weight Z score, body mass index Z score of breast milk enhancer group showed a significant increase in corrected age at 1, 2 months and 3 months （P < 0.05), growth deviation rate was significantly lower （P < 0.05), incidence of infection within 3 months corrected age decreased significantly （P < 0.05). However, there were no statistically significant differences in the incidence of feeding intolerance, retinopathy of prematurity, necrotizing enterocolitis and bronchopulmonary dysplasia, and INFANIB scores between the two groups （P > 0.05). Conclusion Breast milk combined with breast milk fortifier can significantly promote the growth and development of VLBW premature infants, reduce the deviation of growth and development, and reduce the incidence of infection, which is worthy of clinical promotion.
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