冠心病患者25羟维生素D、内皮素水平与冠状动脉病变程度的关系

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Abstract Objective To study the relationship between the level of 25 hydroxy vitamin D [25(OH)D] and endothelin (ET) and the severity of coronary artery disease in patients with coronary heart disease (CHD). Methods From September 2017 to August 2018, 200 patients with CHD admitted to the Second People′s Hospital of Guangdong Province (hereinafter referred to as "our hospital") were selected as CHD group, which was divided into 89 patients of mild lesion group, 66 patients of moderate lesion group and 45 patients of severe lesion group according to Gensini score. Another 60 normal persons who received physical examination in our hospital in the same period were taken as normal control group. General data between CHD group and normal control group was compared. The levels of serum 25(OH)D and plasma ET in four groups were measured, and the correlation and multivariate Logistic regression analysis were carried out. Results The levels of total cholesterol, triglyceride and low-density lipoprotein cholesterol in CHD group were higher than those in normal control group, the difference was statistically significant (P < 0.05). Serum levels of 25(OH)D in the mild, moderate and severe lesions groups were lower than those in normal control group, the serum levels of 25(OH)D in moderate and severe lesions groups were lower than those in mild lesion group, and the serum level of 25(OH)D in severe lesion group was lower than that in moderate lesion group (P < 0.05). Serum levels of ET in mild, moderate and severe lesions groups were higher than those in normal control group, serum levels of ET in moderate and severe lesions groups were higher than those in mild lesion group, and serum level of ET in severe lesion group was higher than that in moderate lesion group (P < 0.05). Pearson correlation analysis showed that serum 25(OH)D level was negatively correlated with Gensini score (r = -0.597, P < 0.05), while ET level was positively correlated with Gensini score (r = 0.644, P < 0.05). Multivariate Logistic regression analysis showed that 25(OH)D was the protective factor of CHD (OR = 0.735, 95%CI: 0.608-0.889, P < 0.05), while ET was the independent risk factor of CHD (OR = 2.498, 95%CI: 1.338-4.663, P < 0.05). Conclusion The decrease of serum 25(OH)D level and the increase of ET level in patients with CHD are closely related to the severity of coronary artery disease. They are risk factors of CHD and are expected to become new clinical diagnostic indicators.

Key words： Coronary heart disease Severity of coronary artery disease 25 hydroxy vitamin D Endothelin

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	CHEN Wuqi XIE Jiajia YANG Yaolin

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CHEN Wuqi XIE Jiajia YANG Yaolin. The relationship between the levels of 25 hydroxy vitamin D and endothelin and the degree of coronary artery disease in patients with coronary heart disease[J]. 中国医药导报, 2019, 16(32): 67-70.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2019/V16/I32/67

[1] Manson JE，Cook NR，Lee IM，et al. Vitamin D supplements and prevention of cancer and cardiovascular disease [J]. N Engl J Med，2019，380（1）：33-44.
[2] 苏翔，赵明芬.冠心病伴焦虑抑郁状态的中医诊疗现状[J].国际中医中药杂志，2019，41（3）：321-322，后插1.
[3] 宋文信，黄国鹏，刘代菊，等.冠状动脉粥样硬化性心脏病患者体内维生素D水平变化的研究[J].重庆医学，2016，45（16）：2250-2251.
[4] 周广朋，张景岚，李刚，等.2型糖尿病合并冠心病患者维生素D、脂联素的表达水平及临床意义[J].贵州医药，2016，40（9）：922-923.
[5] 刘天城，周白丽.维生素D和同型半胱氨酸与心血管疾病关系的研究进展[J].心血管病学进展，2017，38（5）：612-616.
[6] 文振超.颅内用取栓支架对家兔血管内皮影响的初步实验研究[D].广州：暨南大学，2018.
[7] Liu SW，Qiao SB，Yuan JS，et al. Association of plasma visfatin levels with inflammation，atherosclerosis and acute coronary syndromes（ACS）in humans [J]. Clin Endocrinol（Oxf），2009，71（2）：202-207.
[8] 闫伟，王有恒，任骞，等.冠心病患者维生素D浓度与颈动脉内中膜厚度相关性研究[J].陕西医学杂志，2015，38（3）：321-323.
[9] Suthar OP，Mathur S，Gupta V，et al. Study of correlation of serum vitamin D levels with arterial stiffness and cardiovascular morbidity in elderly individuals of western rajasthan [J]. J Assoc Physicians India，2018，66（3）：18-21.
[10] 李孝辉，王云，霍青，等.维生素D补充联合规范化二级防治方案对冠心病患者的临床价值[J].国际检验医学杂志，2018，39（7）：840-843.
[11] 胡文兰，陈游洲，王继红，等.维生素D缺乏与急性冠状动脉综合征发生风险的相关性研究[J].中国心血管杂志，2018，23（3）：237-241.
[12] 罗梦莹，邹德玲.维生素D缺乏与冠状动脉粥样硬化性心脏病的相关性研究进展[J].中国医师进修杂志，2018， 41（11）：1053-1056.
[13] 马长颖.血脂异常水平与冠心病发病的相关性研究[J].中国城乡企业卫生，2019，34（1）：19-21.
[14] 魏引，何亚磊，蔡叶锐，等.冠心病病人血浆Hcy、CRP、Lp（a）、25（OH）D的表达及临床意义[J].中西医结合心脑血管病杂志，2018，16（8）：1072-1074.
[15] 陈益民，李玲，曾艳萍，等.血清25羟维生素D对2型糖尿病患者并发冠心病的预测价值[J].中国循证心血管医学杂志，2018，10（10）：1247-1249.
[16] 周广朋，张景岚，李刚，等.冠心病合并2型糖尿病患者维生素D、胰岛素受体的表达水平及临床意义[J].成都医学院学报，2015，10（2）：177-179.
[17] 代永红，耿艳秋，刘建光，等.2型糖尿病患者血清维生素D水平及影响因素分析[J].临床内科杂志，2014，31（2）：132-133.
[18] 徐向聪.老年ACS患者血清25-羟维生素D及血脂变化与冠心病关系探讨[J].深圳中西医结合杂志，2018， 28（10）：84-86.
[19] 叶娟.维生素D缺乏与冠状动脉旁路移植术后心房颤动的研究进展[J].心血管病学进展，2018，39（6）：896-899.
[20] Liu Y，Peng W，Li Y，et al. Vitamin D deficiency harms patients with coronary heart disease by enhancing inflammation [J]. Med Sci Monit，2018，24（24）：9376-9384.