|
|
|
| Effect of Jinbei Tankeqing Particles combined with Diprophylline in the treatment of elderly patients with acute exacerbation of chronic bronchitis |
| HUANG Ying1 LIU Qiongjiao1 GONG Zonglian2 |
| 1.Department of Geriatric Diseases, Nanchong Mental Health Center (the Second People′s Hospital of Nanchong City), Sichuan Province, Nanchong 637000, China; 2.Department of Respiratory Medicine, Affiliated Hospital of North Sichuan Medical College, Sichuan Province, Nanchong 637000, China |
|
|
|
Abstract Objective To explore clinical efficacy and safety of Jinbei Tankeqing Particles combined with Diprophylline in the treatment of elderly patients with acute exacerbation of chronic bronchitis. Methods From January 2017 to January 2019， 109 cases of elderly patients with acute exacerbation of chronic bronchitis in Nanchong Mental Health Center (the Second People′s Hospital of Nanchong City) were selected. According to the random number table method, they were divided into control group (n = 54) and observation group (n = 55). Patients of control group were treated with Diprophylline, while observation group were treated with Jinbei Tankeqing Particles combined with Diprophylline, both groups were treated for 2 weeks. Clinical curative effect was evaluated after treatment. The cough up phlegm, cough disappeared, then sound and wheezing disappeared times of the two groups were compared. The arterial partial pressure of oxygen (PaO2), oxyhemoglobin saturation (SpO2), partial pressure of carbon dioxide in artery (PaCO2) and serum levels of interleukin (IL)-4, IL-6, tumor necrosis factor-α (TNF-α) of the two groups before and after treatment were compared. The adverse reactions of the two groups were recorded. Results The total clinical effective rate of observation group was higher than that of control group, the difference was statistically significant (P < 0.05). The cough up phlegm, cough, then sound and wheezing disappeared times of observation group were significantly less than those of control group, the differences were statistically significant (P < 0.05). After treatment, the PaCO2 of two groups were significantly lower than those before treatment, the PaO2, SaO2 of the two groups were significantly higher than those before treatment, the differences were statistically significant (P < 0.05). And the PaO2, SaO2, PaCO2 of observation group were significantly greater than those of control group, the differences were statistically significant (P < 0.05). After treatment, the serum levels of IL-4, IL-6, TNF-α of the two groups were significantly lower than before treatment, and those of observation group were lower than control group, the differences were statistically significant (P < 0.05). Conclusion Jinbei Tankeqing Particles combined with Diprophylline in the treatment of elderly patients with acute exacerbation of chronic bronchitis has a good efficacy and low adverse reactions. It can improve the clinical symptoms and blood gas analysis indexes, reduce the inflammatory factor levels.
|
|
|
|
|
|
[1] 付英杰.玉屏风散加味结合西医常规疗法治疗慢性支气管炎急性发作临床研究[J].国际中医中药杂志，2017，39（11）：985-988.
[2] 金瑞凡.清金化痰汤加减治疗痰热郁肺型慢性支气管炎急性发作期的临床效果观察[J].中外医学研究，2019，17（8）：31-32.
[3] 王俊.探究慢性支气管炎在呼吸内科治疗的效果[J].中西医结合心血管病电子杂志，2019，7（1）：71.
[4] 宋燕平，谢春梅，刘明明.左氧氟沙星与氨溴索联用对慢性支气管炎患者的临床疗效评价[J].抗感染药学，2017， 14（8）：1560-1561.
[5] 张海涛.中西药合用治疗慢性支气管炎急性发作临床观察[J].实用中医药杂志，2019，35（2）：191-192.
[6] 杨积宝，方英岳，刑春喜.金贝痰咳清颗粒联合孟鲁司特钠治疗儿童喘息性支气管炎的临床研究[J].现代药物与临床，2019，34（3）：750-754.
[7] 陈灏珠.实用内科学[M].11版.北京：人民卫生出版社，2001：1449-1453.
[8] 郑筱萸.中药新药临床研究指导原则[M].北京：中国医药科技出版社，2002：57-58.
[9] 张勇，王志颐，江满杰，等.蒲地蓝消炎口服液治疗慢性支气管炎急性发作临床研究[J].中国药业，2015，24（3）：16-18.
[10] 周晓峰.二羟丙茶碱联合氨溴索治疗急性发作期慢支的临床效果[J].航空航天医学杂志，2014，25（10）：1429-1430.
[11] 黄巾休.东莨菪碱联合二羟丙茶碱佐治小儿毛细支气管炎疗效观察[J].基层医学论坛，2016，20（S1）：33-34.
[12] 程惠然.中西医联合治疗慢性支气管炎急性发作的临床研究[J].基层医学论坛，2019，23（5）：681-682.
[13] 陈晨.中医辨证疗法对慢性支气管炎急性发作期及缓解期的康复探讨[J].双足与保健，2017，26（17）：196，198.
[14] 赵琳.金贝痰咳清颗粒治疗慢性喘息性支气管炎急性发作期的疗效观察[J].临床合理用药杂志，2012，5（24）：76-77.
[15] 冉霞.金贝痰咳清颗粒治疗慢性支气管炎的疗效观察[J].临床合理用药杂志，2012，5（21）：73.
[16] 王芳杰，崔虎啸，史广超.三子止咳胶囊联合二羟丙茶碱治疗慢性支气管炎急性发作的临床研究[J].现代药物与临床，2018，33（12）：3212-3215.
[17] 李洁锋.氨溴索联合α-糜蛋白酶治疗慢性支气管炎急性发作患者的疗效及对炎症水平因子的影响[J].慢性病学杂志，2016，17（11）：1256-1258.
[18] 王茸，宋莹，徐彩姝，等.支气管哮喘患儿急性发作期血清IL-1β和IL-4水平的检测[J].检验医学与临床，2014（Z2）：282-283.
[19] 尤勇.老年慢性支气管炎患者急性发作期血清肿瘤坏死因子-α、白细胞介素-6含量变化及对预后的影响[J].中国老年学杂志，2014，34（3）：680-681.
[20] 潘美妮，罗维贵，李林霖，等.IL-6与慢性阻塞性肺疾病关系的研究进展[J].医学综述，2018，24（24）：4796-4801，4807.
[21] 王宽，刘艳红，杨惠卫，等.小柴胡颗粒联合盐酸氨溴索雾化对慢性支气管炎急性发作期患者临床疗效的影响[J].现代生物医学进展，2017，17（15）：2865-2868.
[22] 陈尚君，费秀斌，蔡栋梁.金贝痰咳清治疗老年慢性支气管炎急性发作疗效观察[J].实用心脑肺血管病杂志，2012，20（1）：138-139. |
|
|
|
