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| Discussion on the new strategy of Compound Chinese Medicine for Reinforcing Kidney for preventing and treating atherosclerosis from the perspective of lipophagy |
| YAN Li JIA Qingling SHEN Dingzhu |
| Shanghai Geriatrics Institute of Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 200031, China |
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Abstract Atherosclerosis (AS) is a multifactorial disease closely related to aging, and lipid accumulation is a key pathological factor. Lipophagy as an important sub-process of autophagy, it can selectively degradate intracellular lipid droplets via lysosome-mediated and reduce lipid deposition, which can be used as a new target for AS research. Adhering to the basic pathogenesis of deficient root and excessive branch, and the basic idea of the combination of disease and syndrome of AS, based on the interaction between autophagy and lipid metabolism in AS process, combined with the preliminary research results that the intervene therapy of AS, the Compound Chinese Medicine for Reinforcing Kidney can effectively delay aging and regulate lipid metabolism, this artical intends to further explore the research strategy of the Compound Chinese Medicine for Reinforcing Kidney prevents and treats AS from the perspective of lipophagy.
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