脓毒症患者血清NGAL、KIM-1、Cys-C对急性肾损伤的诊断能效

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Abstract Objective To explore the diagnostic value of serum neutrophil gelatinase-associated lipocalin (NGAL), kidney injury molecule-1 (KIM-1) and cystatin C (Cys-C) for acute kidney injury (AKI) in sepsis patients. Methods A total of eithty-nine patients with sepsis admitted to ICU of Weifang Traditional Chinese Medicine Hospital of Shondong Province were observed continuously for 48 hours, who were divided into AKI group (42 cases) and non-AKI group (47 cases) according to the presence of AKI. Serum NGAL, KIM-1 levels were measured by double antibody sandwich enzyme-labeled immunoassay at 0, 6, 12, 24, 48 hous after admission, while serum Cys-C level was detected by immunoturbidimetry. Results Serum NGAL, KIM-1, and Cys-C levels were compared between the two groups at different time points, and the differences were statistically significant (P ＜ 0.05). The serum levels of NGAL, KIM-1 and Cys-C in AKI group were higher than those in non-AKI group at the same time, and the differences were statistically significant (P ＜ 0.05). Serum NGAL was positively associated with KIM-1 and Cys-C in AKI group, while serum KIM-1 was positively associated with Cys-C (P ＜ 0.05). Serum NGAL, KIM-1 and Cys-C have high predictive value for AKI in sepsis patients at 6 hours after admission, and the area under ROC curve was 0.891 (95%CI: 0.869-0.972), the sensitivity and specificity were 0.93 and 0.87, respectively, while the accuracy was 0.91. Conclusion Combined detection of serum NGAL, KIM-1 and Cys-C can predict early AKI in sepsis patients, which has certain clinical reference significance.

Key words： Sepsis Acute kidney injury Neutrophil gelatinase-associated lipocalin Kidney injury molecule-1 Cystatin C Diagnostic value

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	LIU Ruiqing1 MENG Zhiyun1 CHU Hongguang2 LI Zhaochun1

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LIU Ruiqing1 MENG Zhiyun1 CHU Hongguang2 LI Zhaochun1. Diagnostic efficacy of serum NGAL, KIM-1 and Cys-C for acute kidney injury in sepsis patients[J]. 中国医药导报, 2019, 16(29): 128-131.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2019/V16/I29/128

[1] 李倩倩，纪晓霞，嵇丹丹.脓毒症并发急性肾损伤患者临床特点及危险因素分析[J].医药前沿，2018，8（36）：156.
[2] 年亚文，胡金玲.尿Netrin-1及IL-18对脓毒症急性肾损伤早期诊断的临床价值[J].黑龙江医药科学，2018，4（30）：96-98.
[3] 程悠悠，黄庆，叶宏伟.NGAL和Cys C对脓毒症相关急性肾损伤的早期诊断学意义[J].华南国防医学杂志，2016， 35（8）：496-499.
[4] 任玉林，陈明桐.肾损伤分子-1与肾细胞癌的研究进展[J].国际泌尿系统杂志，2018，38（2）：295-298.
[5] Saydam O，Turkmen E，Portakal O，et al. Emerging biomarker for predicting acute kidney injury after cardiac surgery：cystatin C [J]. Turk J Med Sci，2018，48（6）：1096-1103.
[6] Coopersmith CM，De Backer D，Deutschman CS，et al. Surviving Sepsis Campaign：Research Priorities for Sepsis and Septic Shock [J]. Crit Care Med，2018，46（8）：1334-1356.
[7] Volpon LC，Sugo EK，Consulin JC，et al. Epidemiology and Outcome of Acute Kidney Injury According to Pediatric Risk，Injury，Failure，Loss，End-Stage Renal Disease and Kidney Disease：Improving Global Outcomes Criteria in Critically Ⅲ Children-A Prospective Study [J]. Pediatr Crit Care Med，2016，17（5）：e229-e238.
[8] 杨兴才，楼丹飞，韦红，等.抗炎合剂对脓毒症患者血管内皮细胞功能的影响[J].国际中医中药杂志，2018，40（7）：587-591.
[9] Poukkanen M，Vaara ST，Pettila V，et al. Acute kidney injury in patients with severe sepsis in Finnish Intensive Care Units [J]. Acta Anaesthesiologica Scandinavica，2013， 57（7）：863-872.
[10] Soni SS，Ronco C，Katz N，et al. Early diagnosis of acute kidney injury：the promise of novel biomarkers [J]. Blood Purif，2009，28（3）：165-174.
[11] 罗旭颖，周建新，席修明.急性肾损伤的诊断：肌酐还是尿量？[J].中华重症医学电子杂志：网络版，2017，3（1）：9-13.
[12] 黄莉莉，缪华杰，陆洋，等.脓毒症患者血清胱抑素C、尿液肾脏损伤分子1水平变化及其对并发急性肾损伤的诊断价值[J].山东医药，2017，57（31）：70-72.
[13] Hoste EA，Vandenberghe W. Plasma neutrophil gelatinase-associated lipocalin（NGAL）for timing of initiation of renal replacement therapy for acute kidney injury [J]. J Thorac Dis，2018，10（33）：S3989-S3993.
[14] 申升，李琴，吴家清，等.血NGAL在肾移植后急性肾损伤早期诊断中的应用[J].中华器官移植杂志，2017，38（5）：277-281.
[15] 龚小波.NGAL对肾移植术后移植肾功能诊断价值的研究进展[J].国际泌尿系统杂志，2018，38（3）：509-513.
[16] Nadim MK，Genyk YS，Tokin C，et al. Impact of the etiology of acute kidney injury on outcomes following liver transplantation： acute tubular necrosis versus hepatorenal syndrome [J]. Liver Transpl，2012，18（5）：539-548.
[17] 柴成国，张建军，李宁，等.肾损伤分子-1在ICU患者感染继发性肾损伤早期诊断中的评价[J].中华医院感染学杂志，2016，26（6）：1316-1318.
[18] Liangos O，Tighiouart H，Perianayagam MC，et al. Comparative analysis of urinary biomarkers for early detection of acute kidney injury following cardiopulmonary bypass [J]. Biomarkers，2009，14（6）：423-431.
[19] 何捷，李达，严一核，等.尿肾损伤分子-1诊断脓毒症急性肾损伤的价值[J].实用医学杂志，2014，30（1）：87-89.
[20] 王丹丹.血清Cys-C、β2-MG与U-ALP检测在糖尿病肾病患者肾功能损害程度评估中的应用[J].慢性病学杂志，2018，19（8）：1093-1094.