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| Relationship between clinical features of different phenotypes of refractory asthma and peripheral blood cells |
| CONG Li1 ZENG Yun2 CHEN Liping1▲ WU Chao1 |
1.Department of Respiratory and Critical Care Medicine, Xinjiang Uygur Autonomous Region People′s Hospital, Xinjiang Uygur Autonomous Region, Urumqi 830001, China;
2.Department of Respiratory and Gastroentry, Xinjiang Uygur Autonomous Region Children′s Hospital, Xinjiang Uygur Autonomous Region, Urumqi 830001, China |
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Abstract Objective To explore and analyze the correlation between different phenotypes of refractory asthma and peripheral blood cells. Methods Eighty-eight patients with refractory asthma admitted to Xinjiang Uygur Autonomous Region People′s Hospital from May 2016 to May 2018 were selected as subjects, while they were enrolled in the sputum cytology. According to different airway inflammation phenotypes, the patients were classified in acidic granulocyte type, neutrophil type, mixed cell type and oligocytic type. The lung function indexes and the peripheral blood counts of patients with different airway inflammation phenotypes were compared. Results Forced expiratory volume in one second (FEV1), FEV1/forced vital capacity(FVC), fractional exhaled nitirc oxide(FeNO) in acidic granulocyte type and mixed cell type patients were significantly higher than those in neutrophil type, and the differences were statistically significant (P ＜ 0.05). FEV1、FEV1/FVC in oligocytic type patients were significantly higher than those in neutrophil type, while FeNo was lower than that in neutrophil type, and the differences were statistically significant (P ＜ 0.05). Neutrophils in acidic granulocyte type and mix cell type patients were significantly lower than those in neutrophil type, while eosinophils were significantly higher than those in neutrophil type, and the differences were statistically significant (P ＜ 0.05). Neutrophils in oligocytic type patients were lower than that in neutrophil type, while lymphocytes were significantly higher than those in neutrophil type, and the differences were statistically significant (P ＜ 0.05). Conclusion There are four phenotypes of airway inflammation in refractory asthma. Among them, the pulmonary function of neutrophil type is poor, and the levels of eosinophils and neutrophils in peripheral blood cells are correlated in assessing the inflammatory phenotype of asthma.
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[1] 赵燕，程晓明，林科雄，等.哮喘急性加重和糖皮质激素治疗对诱导痰炎症细胞分类及表型的影响[J].第三军医大学学报，2013，35（18）：1968-1970．
[2] Chung KF，Wenzel SE，Brozek JL，et al. International ERS/ATS guidelines on definition，evaluation and treatment of severe asthma [J]. Eur Respir J，2014，43（2）：343-373.
[3] 陈翠仪，程远雄，陈美华.哮喘气道炎症表型与病情严重程度与治疗效果的相关性研究[J].中国药业，2015，24（3）：10-11.
[4] 中华医学会呼吸病学分会哮喘学组，中华医学会全科医学分会.中国支气管哮喘防治指南（基层版）[J].中华结核和呼吸杂志，2013，36（5）：23-24.
[5] 黄慧，李珊，徐作军.特发性间质性肺炎国际多学科分类新标准（摘译）——美国胸科学会/欧洲呼吸病学会官方共识[J].中华结核和呼吸杂志，2014，37（9）：89-90.
[6] 徐华君.必可酮联合酮替芬对支气管炎患者痰中嗜酸性粒细胞的影响[J].中国药业，2013，22（4）：9-10.
[7] 肖天赐.定喘汤联合西医常规治疗对过敏性支气管哮喘患者外周血单个核细胞Th1/Th2及黏膜免疫功能的影响[J].河北中医，2017，39（7）：34-35.
[8] 杜春玲，徐侃，闵智慧，等.外周血CD4+记忆T细胞的表型及其与支气管哮喘严重程度的相关性[J].中华医学杂志，2017，97（30）：45-46.
[9] 刘振千，王凡，陈韦.晚发型重度难治性哮喘气道炎症表型与激素疗效的临床研究[J].中华肺部疾病杂志：电子版，2018，11（1）：78-79.
[10] 赵冰，潘家华.学龄前儿童反复喘息相关危险因素Logistic回归分析[J].安徽医科大学学报，2015，20（8）：1154-1156.
[11] 李爱霞，徐峰.沙丁胺醇联合布沙美特罗替卡松治疗支气管哮喘的疗效及对外周血嗜酸性粒细胞指标的影响[J].湖南师范大学学报：医学版，2019，6（1）：56-57.
[12] 何春卉，林俊宏，陈容珊，等.孟鲁司特钠联合丙酸氟替卡松治疗螨虫过敏的儿童咳嗽变异型哮喘的疗效及安全性[J].中华实用儿科临床杂志，2015，34（14）：1106-1109.
[13] 李芙蓉，王捷军.儿童支气管哮喘控制不良因素中鼻窦炎患病率观察[J].中国实用内科杂志，2014，25（5）：106-108.
[14] 单文婕，卢燕鸣，李亚琴，等.婴幼儿反复喘息危险因素Meta分析[J].中华实用儿科临床杂志，2015，30（10）：761-764.
[15] 王亚琴，杨夏，蔡海燕，等.支气管哮喘儿童个性特征的对照研究[J].临床与实践，2017，15（33）：30-31.
[16] 古力鲜·马合木提，穆清爽，努尔阿米娜·铁力瓦尔地，等.支气管哮喘不同表型的PDGF及VEGF表达水平及其意义[J].临床和实验医学杂志，2017，16（12）：45-46.
[17] 王子江.532例哮喘患者的气道炎症表型及临床特征分析[J].山东医药，2016，56（9）：23-24.
[18] 王恋，颜浩，王玉珠，等.IL-32在不同分期哮喘患者血清中的表达比较[J].临床输血与检验，2018，20（2）：29-30.
[19] 赵茜叶，赵德育.儿童难治性哮喘的识别与处理[J].中华实用儿科临床杂志，2018，3（16）：56-57.
[20] 康瑞.低温等离子射频腺样体消融加扁桃体切除术治疗儿童SAHS对难治性哮喘的影响[J].临床心身疾病杂志，2017，23（4）：234-235. |
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