舒更葡糖对术后恶心呕吐影响的Meta分析

Abstract
Figure/Table
References (31)
Related Citation (15)

Download: PDF (1423 KB) HTML (1 KB)
Export: BibTeX | EndNote (RIS)

Abstract Objective To evaluate the effect of Sugammadex on postoperative nausea and vomiting. Methods The randomized controlled trials related to Sugammadex and postoperative nausea and vomiting were collected from PubMed, Embase, The Cochrane Library, CNKI and Wanfang databases. This meta-analysis was performed by Stata 15 software. Results Finally 21 RCT with 2248 patients were included. The meta-analysis showed that Sugammadex was better than Neostigmine in reducing the incidence of postoperative nausea and vomiting (RR = 0.69, 95%CI: 0.57-0.85, P ＜ 0.001), and 2 mg/kg group could lower the incidence of postoperative nausea and vomiting (RR = 0.69, 95%CI: 0.54-0.87, P ＜ 0.01), but 4 mg/kg could not lower the incidence of postoperative nausea and vomiting (RR = 0.71, 95%CI: 0.50-1.02, P ＞ 0.05). Conclusion Sugammadex is better than Neostigmine in reducing the incidence of postoperative nausea and vomiting.

Key words： Sugammadex Bridion Neostigmine Postoperative nausea and vomiting Meta-analysis

	Service

	E-mail this article
	Add to my bookshelf
	Add to citation manager
	E-mail Alert
	RSS
	Articles by authors
	GAO Wenli YUAN Ruixia XING Yanmei RUAN Shanshan ZHU Yi LIN Miao DAI Zhongliang

Cite this article:

GAO Wenli YUAN Ruixia XING Yanmei RUAN Shanshan ZHU Yi LIN Miao DAI Zhongliang. Effect of Sugammadex on postoperative nausea and vomiting：a meta-analysis[J]. 中国医药导报, 2019, 16(29): 112-117.

URL:

http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2019/V16/I29/112

[1] 赵莹，姜陆洋.新型肌松拮抗药舒更葡糖[J].中国新药杂志，2017，26（23）：2767-2771.
[2] Keating GM. Sugammadex：A Review of Neuromuscular Bl-ockade Reversal [J]. Drugs，2016，76（10）：1041-1052.
[3] Cada DJ，Levien TL，Baker DE. Sugammadex [J]. Hosp Pharm，2016，51（7）：585-596.
[4] Hristovska AM，Duch P，Allingstrup M，et al. Efficacy and safety of sugammadex versus neostigmine in reversing neuromuscular blockade in adults [J]. Cochrane Database Syst Rev，2017，8：CD012763.
[5] Flockton EA，Mastronardi P，Hunter JM，et al. Reversal of rocuronium-induced neuromuscular block with sugammadex is faster than reversal of cisatracurium-induced block with neostigmine [J]. Br J Anaesth，2008，100（5）：622-630.
[6] Jones RK，Caldwell JE，Brull SJ，et al. Reversal of profound rocuronium-induced blockade with sugammadex：a randomized comparison with neostigmine [J]. Anesthesiology，2008，109（5）：816-824.
[7] Blobner M，Eriksson LI，Scholz J，et al. Reversal of rocuronium-induced neuromuscular blockade with sugammadex compared with neostigmine during sevoflurane anaesthesia：results of a randomised，controlled trial [J]. Eur J Anaesthesiol，2010，27（10）：874-881.
[8] Khuenl-Brady KS，Wattwil M，Vanacker BF，et al. Sugammadex provides faster reversal of vecuronium-induced neuromuscular blockade compared with neostigmine：a multicenter，randomized，controlled trial [J]. Anesth Analg， 2010，110（1）：64-73.
[9] Lemmens HJ，El-Orbany MI，Berry J，et al. Reversal of profound vecuronium-induced neuromuscular block under sevoflurane anesthesia：sugammadex versus neostigmine [J]. BMC Anesthesiol，2010，10（1）：15.
[10] Illman HL，Laurila P，Antila H，et al. The duration of residual neuromuscular block after administration of neostigmine or sugammadex at two visible twitches during train-of-four monitoring [J]. Anesth Analg，2011，112（1）：63-68.
[11] Sabo D，Kevin Jones R，Berry J，et al. Residual Neuromuscular Blockade at Extubation：A Randomized Comparison of Sugammadex and Neostigmine Reversal of Rocuronium-Induced Blockade in Patients Undergoing Abdominal Surgery [J]. J Anesth Clin Res，2011，2（6）.
[12] Woo T，Kim KS，Shim YH，et al. Sugammadex versus neostigmine reversal of moderate rocuronium-induced neuromuscular blockade in Korean patients [J]. Korean J Anesthesiol，2013，65（6）：501-507.
[13] Castro DS，Leao P，Borges S，et al. Sugammadex reduces postoperative pain after laparoscopic bariatric surgery：a randomized trial [J]. Surg Laparosc Endosc Percutan Tech，2014，24（5）：420-423.
[14] Ozgun C，Cakan T，Baltaci B，et al. Comparison of reversal and adverse effects of sugammadex and combination of - anticholinergic-anticholinesterase agents in pediatric patients [J]. J Res Med Sci，2014，19（8）：762-768.
[15] Wu X，Oerding H，Liu J，et al. Rocuronium blockade reversal with sugammadex vs. neostigmine：randomized study in Chinese and Caucasian subjects [J]. BMC Anesthesiol，2014，14：53.
[16] Brueckmann B，Sasaki N，Grobara P，et al. Effects of sugammadex on incidence of postoperative residual neuromuscular blockade：a randomized，controlled study [J]. Br J Anaesth，2015，115（5）：743-751.
[17] Koc F. Comparison of Sugammadex and Neostigmine in Short Term Surgery [J]. J Clin Anal Med，2015，6（1）：41-45.
[18] Koyuncu O，Turhanoglu S，Ozbakis Akkurt C，et al. Comparison of sugammadex and conventional reversal on postoperative nausea and vomiting：a randomized，blinded trial [J]. J Clin Anesth，2015，27（1）：51-56.
[19] Rahe-Meyer N，Berger C，Wittmann M，et al. Recovery from prolonged deep rocuronium-induced neuromuscular blockade：a randomized comparison of sugammadex reversal with spontaneous recovery [J]. Der Anaesthesist，2015，64（7）：506-512.
[20] Putz L，Dransart C，Jamart J，et al. Operating room discharge after deep neuromuscular block reversed with sugammadex compared with shallow block reversed with neostigmine：a randomized controlled trial [J]. J Clin Anesth，2016，35：107-113.
[21] Ammar AS，Mahmoud KM，Kasemy ZA. A comparison of sugammadex and neostigmine for reversal of rocuronium-induced neuromuscular blockade in children [J]. Acta Anaesthesiol Scand，2017，61（4）：374-380.
[22] Tas Tuna A，Palabiyik O，Orhan M，et al. Does Sugammadex Administration Affect Postoperative Nausea and Vomiting After Laparoscopic Cholecystectomy：A Prospective，Double-Blind，Randomized Study [J]. Surg Laparosc Endosc Percutan Tech，2017，27（4）：237-240.
[23] Yagan O，Tas N，Mutlu T，et al. Comparison of the effects of sugammadex and neostigmine on postoperative nausea and vomiting [J]. Braz J Anesthesiol，2017，67（2）：147-152.
[24] Paech MJ，Kaye R，Baber C，et al. Recovery characteristics of patients receiving either sugammadex or neostigmine and glycopyrrolate for reversal of neuromuscular block：a randomised controlled trial [J]. Anaesthesia，2018，73（3）：340-347.
[25] Hakimo■lu S，Tuzcu K，Davarc?覦 I，et al. Comparison of sugammadex and neostigmine-atropine on intraocular pressure and postoperative effects [J]. Kaohsiung J Med Sci，2016，32（2）：80-85.
[26] Kim YS，Cha JR，Lee YS，et al. Sugammadex affects emergence agitation in children undergoing strabismus surgery [J]. J Int Med Res，2018，46（9）：3861-3872.
[27] Kang HY，Park SW，Lee S，et al. Effect of prophylactic palonosetron and sugammadex on postoperative nausea and vomiting in patients undergoing microvascular decompression under propofol-maintained anesthesia：A retrospective observational study [J]. Medicine，2018，97（46）：e13237.
[28] Lee OH，Choi GJ，Kang H，et al. Effects of sugammadex vspyridostigmine-glycopyrrolate on post-operative nausea and vomiting：propensity score matching [J]. Acta Anaesthesiol Scand，2017，61（1）：39-45.
[29] Amorim P，Lagarto F，Gomes B，et al. Neostigmine vssugammadex：observational cohort study comparing the quality of recovery using the Postoperative Quality Recovery Scale [J]. Acta Anaesthesiol Scand，2014，58（9）：1101-1110.
[30] Tramer MR，Fuchs-Buder T. Omitting antagonism of neuromuscular block：effect on postoperative nausea and vomiting and risk of residual paralysisA systematic review [J]. Br J Anaesth，1999，82（3）：379-386.
[31] Chhibber AK，Lustik SJ，Thakur R，et al. Effects of anticholinergics on postoperative vomiting，recovery，and hospital stay in children undergoing tonsillectomy with or without adenoidectomy [J]. Anesthesiology，1999，90（3）：697-700.