白细胞介素-17A水平及基因多态性与宫颈癌相关性

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Abstract Objective To investigate the correlation between the serum levels of interleukin-17 A(IL-17A) and gene polymorphisms with cervical cancer. Methods From March 2012 to March 2016, 185 patients with cervical cancer treated by surgery in Guiyang Maternal and Child Health Hospital ("our hospital" for short) were selected as the study group, and 185 healthy women who underwent physical examination in the outpatient department at the same time were selected as the control group. Enzyme-linked immunosorbent assay was used to detected the serum levels of IL-17A of both groups. The genotypes of IL-17A promoter rs2275913 (G/A) were analyzed by Taqman probe. The correlation between the IL-17A gene polymorphism with the clinicopathological characteristics and susceptibility cervical of cancer were analyzed. The correlation between the serum levels of IL-17A and gene polymorphisms with genetic susceptibility of cervical cancer were analyzed. Results The serum levels of IL-17A in the study group were significantly higher than those in the control group, the differences were highly statistically significant (P = 0.000). Genotype AG appeared more frequently in both groups, the frequency of genotype AA in the study group was higher than the genotype GG, while the control group did the opposite, the differences were highly statistically significant (P = 0.006). Compared with the control group, the occurrence frequency of allele A in the study group was higher than that of allele G, the difference was highly statistically significant (P = 0.007). Compared with genotype GG, genotype AA had a significantly higher risk of cervical cancer (P = 0.006, OR = 2.31, 95%CI: 1.27-4.20), but there was no significantly increased risk in genotype AG. Allele frequency of IL-17A were correlated with clinical stages (P = 0.001, OR = 0.48, 95%CI: 0.32-0.73）, degree of differentiation (P = 0.000, OR = 2.21, 95%CI: 1.46-3.36）, vascular invasion(P = 0.040, OR = 1.53, 95%CI: 1.01-2.31）and lymph node metastasis (P = 0.003, OR = 0.52, 95%CI: 0.34-0.80）. The mean serum IL-17A levels in two groups was 35 ng/L. People with serum IL-17A < 35 ng/L, the risk of cervical cancer in the genotype AA group was 1.995 times (95%CI: 0.880-4.520), but people with serum IL-17A ≥ 35 ng/L, the risk of cervical cancer in the genotype AA group increased to 2.500 times (P = 0.049, 95%CI: 1.000-6.230). Conclusion IL-17A and its gene polymorphism may be related to the genetic susceptibility of cervical cancer and the occurrence and development of cervical cancer.

Key words： Interleukin-17A Gene polymorphism Cervical cancer

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	LAI Ting ZHU Yan CHEN Lin

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LAI Ting ZHU Yan CHEN Lin. Correlation between the serum levels of interleukin-17A and gene polymerphisms with cervical cancer[J]. 中国医药导报, 2019, 16(29): 84-87,95.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2019/V16/I29/84

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