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| Risk factors analysis and intervention strategies of asymptomatic intracranial artery stenosis patients for developing ischemic stroke |
| ZHOU Xuejiao DENG Yongmei ZHANG Qian |
| Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, China |
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Abstract Objective To analyze the clinical characteristics of asymptomatic intracranial artery stenosis (AIAS) patients and identify the risk factors associated with stroke and propose intervention measures. Methods From January 2016 to December 2017, 122 patients who diagnosed with AIAS in Beijing Tiantan Hospital, Capital Medical University, were selected as study subjects, follow-up of 1-year. During this period, stroke patients were included in the positive group (n = 21) and patients without stroke were included in the negative group (n = 101). The clinical characteristics of two groups were compared, the risk factors of stroke in AIAS patients were analyzed. Results The propotion of hypertension, drinking and smoking in the positive group was higher than those in the negative group, the content of triacylglycerol (TG) was higher than that in the negative group, the relative expression of miRNA-223 was lower than that in the negative group, the differences were statistically significant (P < 0.05). There were no significant differences in body mass index, history of diabetes, albumin, homocysteine, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, total cholesterol, degree of vascular stenosis and number of lesion vessels between the two groups (P > 0.05). Logistic regression analysis showed that smoking, drinking, TG ≥ 1.98 mmol/L and relative expression of miRNA-223 ≤ 0.56 were high risk factors for stroke in AIAS patients (P < 0.05). In the prediction of stroke in AIAS patients, the relative expression of miRNA-223 had higher prediction value than the content of TG. Conclusion Smoking, drinking, TG ≥1.98 mmol/L and relative expression of microRNA-223 ≤0.56 are high risk factors for AIAS patients to develop ischemic stroke. Health education, quitting smoking and alcohol, healthy diet, regularly checking relevant indicators, necessary drug treatment were required in AIAS patients.
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