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| Relationship between serum visfatin level and oxidative stress and carotid atherosclerosis in patients with coronary heart disease |
| ZHONG Su1 YU Yan1 SU Xiaojuan2 WU Yongxin3 |
1.Cadre Ward, Success Hospital Affiliated to Xiamen University, Fujian Province, Xiamen 361000, China;
2.Department of Geriatric, Xiamen Branch of Zhongshan Hospital Affiliated to Fudan University, Fujian Province, Xiamen 361015, China;
3.Department of Cerebral Surgery, HaiDu Hospital of Nan′an, Fujian Province, Nan′an 362342, China |
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Abstract Objective To study the relationship between serum visfatin level and oxidative stress and carotid atherosclerosis in patients with coronary heart disease. Methods Eighty patients with coronary heart disease admitted to Success Hospital Affiliated to Xiamen University (“our hospital” for short) from January 2017 to January 2018 were selected as the study group. According to Gensini scores, the patients were divided into mild atherosclerosis group (29 cases), moderate atherosclerosis group (25 cases) and severe atherosclerosis group (26 cases). While matching of sex, age, blood pressure, blood sugar and blood lipid, eighty patients with non-coronary heart disease admitted to our hospital during the same period were selected as the control group. The levels of biochemical indicators, serum visfatin, malondialdehyde (MDA) and superoxide dismutase (SOD) were compared between the two groups, respectively. And the relationship between SOD, MDA and the severity of carotid atherosclerosis and the level of serum visfatin were analyzed. Results There were no statistically significant differences in blood pressure, blood sugar and blood lipid between the two groups (P ＞ 0.05). The serum visfatin and MDA in the study group were significantly higher than those in the control group, while the serum SOD in the study group was significantly lower than that in the control group, and the differences were statistically significant (P ＞ 0.05). Serum visfatin and MDA levels in mild atherosclerosis group were higher than those in moderate atherosclerosis group, while SOD levels were lower than that in mild atherosclerosis group, and the differences were statistically significant (P ＜ 0.05). Serum visfatin and MDA levels in severe atherosclerosis group were statistically higher than those in mild and moderate atherosclerosis group, while SOD levels was lower than that in mild and moderate atherosclerosis group, and the differences were statistically significant (P ＜ 0.05). Serum visfatin levels were positively correlated with serum MDA levels and Gensini score (r = 0.587, 0.634, P < 0.05), while negatively correlated with SOD levels (r = -0.609， P ＜ 0.05). Conclusion The serum visfatin levels in patients with coronary heart disease are significantly higher and closely related to oxidative stress and carotid atherosclerosis. Serum visfatin level can be detected in clinical work, which is helpful to assess oxidative stress and severity of carotid atherosclerosis. It is worthy of clinical application.
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