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| Progress in research on ubiquitination in the field of reproduction |
| YU Jiarui1 CONG Jing2 ZHANG Ming3 WU Xiaoke2 |
1.Heilongjiang University of Chinese Medicine, Heilongjiang Province, Harbin 150040, China;
2.the First Department of Obstetrics and Gynecology, the First Affiliated Hospital of Heilongjiang University of Chinese Medicine, Heilongjiang Province, Harbin 150040, China;
3.Department of Infection Control Management, Wang Jing Hospital of China Academy of Chinese Medical Sciences, Beijing 100102, China |
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Abstract Ubiquitin is a highly evolutionarily conserved small protein found in most eukaryotic cells. Ubiquitin can form a three-step cascade through ubiquitin-activating enzyme E1, ubiquitin-binding enzyme E2, and ubiquitin-binding enzyme E3, respectively, and bind to the target protein, ubiquitinates the target protein, then passes through the ubiquitin-proteasome degradation pathway. The ubiquitinated target protein is broken down into smaller polypeptides and amino acids. Ubiquitination can affect the transcriptional activity of estrogen and progesterone receptors and participate in processes in the reproductive field such as oocyte, spermatogenesis and embryonic development. This article reviews recent research in the field of ubiquitination and reproduction, explores the role of ubiquitination in reproduction is of great significance for further mastering the development of germ cells and early embryo development, and provides a theoretical basis for the treatment of infertility and perfecting the reproductive system.
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