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| Research progress of the application of ubiquitin proteasome pathway |
| DONG Huilin1 NIE Hongming1 MEI Zhaohe2 ZHAO Binbin2 JIANG Yuzi2 CHEN Jianjie1 WANG Lingtai1 |
1.Department of Hepatology, Shuguang Hospital Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China;
2.Shuguang Clinical Medical College, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China |
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Abstract The ubiquitin proteasome pathway which is dependent on ATP has a highly specific and selective protein degradation pathway. UPP exists in eukaryotic cells widely, and plays an important role in cell cycle regulation, signal transduction, antigen presentation, immune response and other biological functions. Currently, it is known that this pathway is closely related to neurodegeneration, viral infection, tumor, cardiovascular and other aspects. Once UPP abnormal affects the function of α-synuclein and Parkin protein, it will lead to Parkinson′s disease. Skp2, E3 ubiquitin ligase c-cbl and ubiquitin ligase E2C in the SCF complex protein are all related to the development of tumors. Many viruses, such as the HCMV virus, can attack or use UPP to evade immune attacks. In addition, many diseases have also been reported to be related to UPP, but at present we know very little about the system, and the related research is far from enough, and more exploration is needed.
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