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| Clinical effect of Cefaclor and Bromhexine Hydrochloride for Suspension in the treatment of acute suppurative tonsillitis in children |
| XU Minghao LIU Honglin |
| Department of Emergency, Kunming Children′s Hospital, Yunnan Province, Kunming 467000, China |
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Abstract Objective To observe the clinical efficacy of Cefaclor and Bromhexine Hydrochloride for Suspension in the treatment of acute suppurative tonsillitis in children. Methods One hundred and twenty children with acute suppurative tonsillitis in Kunming Children′s Hospital from June 2017 to June 2018 were randomly divided into the observation group (60 cases) and the control group (60 cases) by random number table method, which were treated with Cefaclor and Bromhexine Hydrochloride for Suspension, Amoxicillin and Clavulanate Potassium Suspension, respectively. Both group continued treatment for 7 days. The clinical efficacy, disappearance time of symptoms and signs, the chamge of tonsil enlargement and white blood cell count, neutrophil and C-reactive protein levels before and after treatment were compared between the two groups. Results The total effective rate of treatment in the observation group was significantly higher than that in the control group, and the difference was statistically significant (P ＜ 0.05). The time of body temperature returning to normal, the disappearance of tonsil purulent secretion and the pharyngeal congestion of the observation group were significantly shorter than those of the control group, and the differences were statistically significant (P ＜ 0.05). After treatment, the tonsil enlargement of the observation group was significantly better than that of the control group, while serum white blood cell count, neutrophil and C-reactive protein levels in the observation were significantly lower than those in the control group, and the differences were statistically significant (P ＜ 0.05). There were no significant differences in the incidence of adverse reactions between the two groups (P ＞ 0.05). Conclusion The treatment of acute suppurative tonsillitis inflammation in children with Cefaclor and Bromhexine Hydrochloride for Suspension is faster and better than Amoxicillin and Clavulanate Potassium Suspension.
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