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| Updates on neuroprotective effects and mechanisms of neuroglobin in epilepsy |
| DU Huan1 MI Man2 GUO Xiangyang3 LIU Manling2 LIU Na3 |
1.Graduate School, Xi′an Medical University, Shaanxi Province, Xi′an 710021, China;
2.Institute of General Medicine, Xi′an Medical University, Shaanxi Province, Xi′an 710021, China;
3.Department of Pediatrics, Shaanxi Provincial People′s Hospital, Shaanxi Province, Xi′an 710068, China |
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Abstract This study reviews and discusses the biological functions of neuroglobin and the neuroprotective effects of neuroglobin in epilepsy and its specific mechanisms. Neuroglobin is mainly involved in the proliferation of neural stem cells, promoting axonal regeneration and reducing oxidative stress levels, regulating apoptosis and autophagy pathways, thereby alleviating acute neuronal damage. The specific mechanism of neuroprotection of neuroglobin in epilepsy is regulating the Pik3k/Akt signaling pathway, the Jak2/Stat3 pathway, and the inhibition of activation of caspase-3 activity, and cooperating with the erythropoietin receptor to initiate the relevant signal transduction pathway. This review provides new ideas for preventing the death of neuronal cells caused by epilepsy and reference for treating brain damage caused by epilepsy.
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