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| Research progress of Keap1-Nrf2/ARE antioxidant pathway in tumors |
| YUN Tuya SU Xiulan |
| Clinical Medicine Research Center, Affiliated Hospital of Inner Mongolia Medical University, Inner Mongolia Autonomous Region, Hohhot 010030, China |
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Abstract Reactive oxygen species can cause cell mutation and induce cell carcinogenesis by attacking deoxyribonucleic acid or ribonucleic acid. Keap1-Nrf2/ARE is an important oxidative stress pathway in the body. As the main effector of this system, Nrf2 can prevent malignant transformation of normal cells and play an anti-cancer role by activating and regulating the expression of various phase Ⅱ detoxifying enzymes in the body. Cellular and animal experiments have shown that Nrf2 can promote the development of tumors and increase the tolerance of cancer cells to chemotherapeutic drugs. Research on signal transduction of Keap1-Nrf2/ARE pathway is essential for cancer prevention, development and targeted therapy.
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[1] Glippa O，Jonna E?魻，Kanerva M，et al. Oxidative stress and antioxidant defense responses in Acartia copepods in relation to environmental factors [J]. PLoS One，2018，13（4）：1-15.
[2] Kang KA，Piao MJ，Ryu YS，et al. Interaction of DNA demethylase and histone methyltransferase upregulates Nrf2 in 5-fluorouracil-resistant colon cancer cells [J]. Oncotarget，2016，7（26）：40594-40620.
[3] Goldstein LD，Lee J，Gnad F，et al. Recurrent loss of NFE2L2 exon 2 is a mechanism for Nrf2 pathway activation in human cancers [J]. Cell Rep，2016，16（10）：2605-2617.
[4] Li C，Cheng L，Wu H，et al. Activation of the KEAP1 NRF2 ARE signaling pathway reduces oxidative stress in Hep2 cells [J]. Mol Med Rep，2018，18（3）：2541-2550.
[5] Micaela A，Mafalda S，Cristina RA，et al. Prognosis of hormone-dependent breast cancer seems to be influenced by KEAP1，NRF2 and GSTM1 genetic polymorphisms [J]. Mol Biol Rep，2019，46（3）：3213-3224.
[6] Sparaneo A，Fabrizio FP，Muscarella LA，et al. Nrf2 and notch signaling in lung cancer：near the crossroad [J]. Oxid Med Cell Longev，2016，10（6）：1-17.
[7] Wang T，Long F，Zhang X，et al. Chemopreventive effects of atractylenolide Ⅱ on mammary tumorigenesis via activating Nrf2-ARE pathway [J]. Oncotarget，2017，8（44）：77500-77514.
[8] Silva MDF，Pruccoli L，Morroni F，et al. The Keap1/Nrf2-ARE pathway as a pharmacological target for chalcones [J]. Molecules，2018，23（7）：1803-1824.
[9] 蒋龙超，唐世孝.Keap1-Nrf2-ARE信号通路及其与胃癌化学预防的研究进展[J].世界华人消化杂志，2014，22（20）：2845-2850.
[10] Ma X，Luo Q，Zhu H，et al. Aldehyde dehydrogenase 2 activation ameliorates CCl4-induced chronic liver fibrosis in mice by up-regulating Nrf2/HO-1 antioxidant pathway [J]. J Cell Mol Med，2018，22（8）：3965-3978.
[11] Taguchi K，Takaku M，Egner PA，et al. Generation of a new model rat：Nrf2 knockout rats are sensitive to aflatoxin B1 toxicity [J]. Toxicol Sci，2016，152（1）：40-52.
[12] Yang WY，Sun ZJ，Yang B，et al. Nrf2-Knockout Protects from Intestinal Injuries in C57BL/6J Mice Following Abdominal Irradiation with γ Rays [J]. Int J Mol Sci，2017， 18（8）：1656-1670.
[13] Sharma RS，Harrison DJ，Kisielewski D，et al. Experimental nonalcoholic steatohepatitis and liver fibrosis are ameliorated by pharmacologic activation of Nrf2 （NF-E2 p45-related factor 2） [J]. Cell Mol Gastroenterol Hepatol，2017，5（3）：367-398.
[14] 李佳.石榴皮多酚对人肝癌细胞HepG2的抗肿瘤活性及其分子机制研究[D].西安：陕西师范大学，2015.
[15] 严展鹏.基于Nrf2/ARE信号通路探讨木犀草素对结直肠癌的化学预防作用及机理研究[D].南京：南京师范大学，2014.
[16] 王宁，刘硕，杨雷，等.2018全球癌症统计报告解读[J].肿瘤综合治疗电子杂志，2019，5（1）：87-97.
[17] 刘金华，赖玉珍，张伟.Keap1-Nrf2/ARE通路在肺癌中的研究进展[J].广东医学，2018，39（4）：633-636.
[18] 朱学应，马冬春，王保明，等.非小细胞肺癌中Keap1-Nrf2信号通路蛋白的表达及与临床病理相关性分析[J].中华疾病控制杂志，2018，22（9）：938-942.
[19] Fabrizio FP，Sparaneo A，Trombetta D，et al. Epigenetic versus genetic deregulation of the KEAP1/NRF2 axis in solid tumors：focus on methylation and noncoding RNAs [J]. Oxid Med Cell Longev，2018，11（3）：1-21.
[20] 宋洋，胡燕萍，王锐.胃癌组织中NrF-2和Ho-1的表达及临床意义[J].中国生化药物杂志，2016，36（9）：146-148.
[21] Kawasaki Y，Ishigami S，Arigami T，et al. Clinicopathological significance of nuclear factor （erythroid-2）-related factor 2 （Nrf2） expression in gastric cancer [J]. BMC Cancer，2015，15（1）：5-12.
[22] Li L，Pan H，Wang H，et al. Interplay between VEGF and Nrf2 regulates angiogenesis due to intracranial venous hypertension [J]. Sci Rep，2016，6（1）：1-11.
[23] 王昕海，巴桑，晋美，等.KEAP1基因突变调控Nrf2-ABCG2信号介导胃癌耐药的研究[J].外科理论与实践，2016（3）：233-237.
[24] Abed DA，Goldstein M，Albanyan H，et al. Discovery of direct inhibitors of Keap1-Nrf2 protein-protein interaction as potential therapeutic and preventive agents [J]. Acta Pharm Sin B，2015，5（4）：285-299.
[25] Namani A，Matiur MR，Chen M，et al. Gene-expression signature regulated by the KEAP1-NRF2-CUL3 axis is associated with a poor prognosis in head and neck squamous cell cancer [J]. BMC Cancer，2018，18（1）：46-57.
[26] 吴媛媛.Keap1/Nrf2信号通路对人肺鳞癌细胞生长、转移和耐药的影响[J].中国老年学杂志，2017，37（9）：2123-2125.
[27] 刘思园，蔡萌，李春建，等.鸦胆子苦醇抑制结直肠癌细胞增殖与Nrf2通路相关性研究[J].中华肿瘤防治杂志，2018，25（4）：243-257.
[28] Tao J，Zhao YQ，Chi CF，et al. Bioactive peptides from cartilage protein hydrolysate of spotless smoothhound and their antioxidant activity in vitro [J]. Mar Drugs，2018，16（4）：100-117.
[29] Sova M，Saso L. Design and development of Nrf2 modulators for cancer chemoprevention and therapy：a review [J]. Drug Des Devel Ther，2018（12）：3181-3197.
[30] Lu Y，Sun Y，Zhu J，et al. Oridonin exerts anticancer effect on osteosarcoma by activating PPAR-γ and inhibiting Nrf2 pathway [J]. Cell Death Dis，2018，9（1）：15-30.
[31] Kapur A，Beres T，Rathi K，et al. Oxidative stress via inhibition of the mitochondrial electron transport and Nrf-2-mediated anti-oxidative response regulate the cytotoxic activity of plumbagin [J]. Sci Rep，2018，8（1）：1073-1088. |
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