羟苯磺酸钙联合降糖药治疗糖尿病视网膜病变伴白内障的临床效果

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Abstract Objective To explore the clinical efficacy of Calcium Dobesilate combined with hypoglycemic agents in the treatment of diabetic retinopathy with cataract. Methods A total of 86 diabetic retinopathy patients (118 eyes) with cataract admitted to Yingkou Central Hospital of Liaoning Province from January 2016 to May 2018 were selected and divided into the control group (43 cases, 60 eyes) and the observation group (43 cases, 58 eyes) according to random number table method. The control group was treated with routine hypoglycemic agents, while the observation group was treated with Calcium Dobesilate on the basis of routine hypoglycemic agents. After 3 months of treatment, the clinical efficacy and adverse drug reactions of the two groups were compared. The naked vision of the two groups before and after treatment was observed, and the blood glucose indexes, hemorheology indexes, the levels of vascular endothelial growth factor (VEGF) and hypoxia-inducible factor (HIF-1α) were detected and compared in the two groups. Results The total effective rate of the clinical efficacy of the observation group was higher than that of the control group, and the difference was statistically significant (P ＜ 0.05). After treatment, the naked vision of both groups was increased compared with that before treatment, and the observation group was higher than the control group (P ＜ 0.05). After treatment, the levels of fasting blood glucose (FBG), 2 h postprandial blood glucose (2hPBG) and glycosylated hemoglobin (HbA1c) in the two groups were reduced compared with those before treatment (P ＜ 0.05). After treatment, erythrocyte deformation index, plasma viscosity, erythrocyte aggregation index, hematocritm, serum VEGF and HIF-1α levels in both groups were reduced compared with those before treatment (P ＜ 0.05), and the above indexes in the observation group were lower than those in the control group (P ＜ 0.05). No adverse reactions were found during treatment in the two groups. Conclusion The combination of routine hypoglycemic agents and Calcium Dobesilate in the treatment of diabetic retinopathy with cataract has a significant effect, which can effectively control blood glucose and improve vision, and medication is safety.

Key words： Diabetic retinopathy Cataract Calcium Dobesilate Blood glucose Hemorheology

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	GUO Jing1 GUO Jing2 CHEN He2

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GUO Jing1 GUO Jing2 CHEN He2. Clinical effect of Calcium Dobesilate combined with hypoglycemic agents in the treatment of diabetic retinopathy with cataract[J]. 中国医药导报, 2019, 16(26): 152-155,171.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2019/V16/I26/152

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