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| Clinical effect of Huatan Jiangqi Huoxue Decoction combined with conventional Western medicine in the treatment of asthma-chronic obstructive pulmonary disease overlap |
| GUO Guanghui1 ZHENG Lan2 YANG Hongzhi1 LI Yue1 YANG Junshu2 |
1.Department of Pulmonary Disease, Hubei Provincial Hospital of Traditional Chinese Medicine, Hubei Province, Wuhan 430060, China;
2.the First Clinical College, Hubei University of Chinese Medicine, Hubei Province, Wuhan 430061, China |
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Abstract Objective To explore the clinical effect of Huatan Jiangqi Huoxue Decoction combined with conventional Western medicine in the treatment of asthma-chronic obstructive pulmonary disease overlap (ACO). Methods One hundred and six patients with ACO admitted to Hubei Provincial Hospital of Traditional Chinese Medicine from June 2017 to December 2018 were selected. They were divided into control group (conventional Western medicine treatment) and study group (Huatan Jiangqi Huoxue Decoction combined with conventional Western medicine treatment) by random number table method, with 53 cases in each group. The clinical efficacy, inflammatory factors, pulmonary function indicators，symptom scores changes and adverse reactions of the two groups were compared. Results After 12 weeks of treatment, the total effective rate of the study group was higher than that of the control group, and the difference was statistically significant (P ＜ 0.05). The first second forced expiratory volume (FEV1), peak expiratory flow (PEF), forced vital capacity (FVC), FEV1/FVC, asthma control test (ACT) score after 12 weeks of treatment in both groups were significantly increased compared with those before treatment, while the study group was significantly higher than the control group, and the differences were statistically significant (P ＜ 0.05). The levels of interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), high-sensitivity C-reactive protein (hs-CRP), and COPD assessment test (CAT) in the two groups after 12 weeks of treatment were significantly lower than those before treatment, while the study group was significantly lower than the control group, and the differences were statistically significant (P ＜ 0.05). There was no statistically significant difference in the incidence of adverse reactions between the two groups (P ＞ 0.05). Conclusion Huatan Jiangqi Huoxue Decoction combined with conventional Western medicine in the treatment of ACO can rapidly improve the clinical symptoms of patients with definite curative effect. At the same time, it can effectively improve the level of inflammatory factors and lung function, and it has better safety.
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[1] Woodruff PG，van den Berge M，Boucher RC，et al. American Thoracic Society/National Heart，Lung，and Blood Institute Asthma-Chronic Obstructive Pulmonary Disease Overlap Workshop Report [J]. Am J Respir Crit Care Med， 2017，196（3）：375-381.
[2] 王彬，吴蔚，张晶，等.基于中医学整体观念的慢性阻塞性肺疾病合并症治疗探讨[J].国际中医中药杂志，2018， 40（8）：765-767.
[3] 刘媛媛，克丽别娜·吐尔逊，迪丽努尔，等.类固醇激素联合β2受体激动剂对哮喘-慢性阻塞性肺疾病重叠综合征的短期疗效[J].实用医学杂志，2017，33（15）：2439-2442.
[4] 诸军英，赵剑，陆俊俏，等.吸入糖皮质激素治疗对哮喘-慢性阻塞性肺疾病重叠综合征合并呼吸衰竭患者血清EOS、IL-6及CRP水平变化的研究[J].临床和实验医学杂志，2017，16（12）：1198-1201.
[5] 陈寒艳，廉海容.补肺活血化痰汤联合正压通气治疗COPD急性加重并发严重呼吸衰竭效果观察[J].山东医药，2017，57（42）：57-59.
[6] 国家中医药管理局.中医内科病证诊断疗效标准（试行）[J].成都中医药大学学报，1995，24（2）：F003-F003.
[7] 郭巍，张继华.支气管哮喘-慢性阻塞性肺疾病重叠综合征的研究进展[J].实用医学杂志，2015，35（8）：1217-1218.
[8] 吴红娟，徐艳秋，张美云，等.天灸对支气管哮喘患者临床症状控制的影响[J].湖南中医杂志，2016，32（12）：84-86.
[9] 徐俊萍，刘姝梅，廉雅曼，等.阿托伐他汀对于稳定期慢性阻塞性肺疾病患者CAT评分、mMRC评分和BODE指数的影响[J].检验医学与临床，2016，13（20）：2971-2974.
[10] 郑筱萸.中药新药临床研究指导原则（试行）[M].北京：中国医药科技出版社，2002.
[11] Araújo D，Padr?觔o E，Morais-Almeida M，et al. Asthma-chronic obstructive pulmonary disease overlap syndrome-Literature review and contributions towards a Portuguese consensus [J]. Rev Port Pneumol（2006），2017， 23（2）：90-99.
[12] 王淑敏，马健，金亚明，等.射干麻黄汤加减联合信必可治疗哮喘-慢性阻塞性肺疾病重叠综合征急性发作期临床研究[J].南京中医药大学学报，2017，33（5）：535-537.
[13] Rokach A，Romem A，Arish N，et al. The Effect of Pulmonary Rehabilitation on Non-chronic Obstructive Pulmonary Disease Patients [J]. Isr Med Assoc J，2019，5（21）：326-329.
[14] 陈岳彪.沙美特罗联合丙酸氟替卡松治疗慢性阻塞性肺疾病的临床研究[J].中国医药科学，2017，7（21）：72-74.
[15] 陈慧芬，谢艳萍，辅桓钦，等.苏黄止咳胶囊联合沙美特罗/丙酸氟替卡松治疗咳嗽变异性哮喘的临床观察[J].中国医药导报，2018，15（9）：105-108.
[16] 王荣宝，杨翠萍，祝晶，等.补肺纳肾平喘方联合信必可治疗哮喘-慢性阻塞性肺疾病重叠综合征[J].吉林中医药，2019，39（2）：212-215.
[17] 王玉民.中医药治疗肺肠相关性疾病研究进展[J].河北中医，2012，34（6）：942-945.
[18] 苏玉国，马淑贞，张国瑛，等.平喘活血汤治疗支气管哮喘120例[J].陕西中医，2011，32（11）：1465-1466.
[19] 刘超，杨金凤，尚刚，等.吸入糖皮质激素联合化痰降气活血方对ACO疗效及FeNO和ET-1水平的影响[J].贵州医科大学学报，2018，43（2）：240-243.
[20] 张念，袁文胜，殷人易，等.清热化痰活血降气法治疗老年热证慢性阻塞性肺疾病患者的疗效观察[J].重庆医学，2016，45（32）：4563-4565.
[21] 何丽霞，吴赛春，李秀存，等.化痰活血方对哮喘小鼠IL-17A和IL-13的影响[J].中成药，2016，38（3）：490-494.
[22] 张念，殷人易，程贵莲，等.化痰活血降气方治疗慢性阻塞性肺疾病急性加重期的抗炎机制[J].实用医学杂志，2016，32（21）：3610-3612. |
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