血清VEGF、bFGF水平与慢性阻塞性肺疾病患者肺动脉高压的关系

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Abstract Objective To investigate the relationship between serum levels of vascular endothelial growth factor (VEGF), basic fibroblast growth factor (bFGF) and pulmonary hypertension (PAH) in patients with chronic obstructive pulmonary disease (COPD). Methods One hundred and forty-three COPD patients admitted to Shanghai Sixth People′s Hospital Affiliated to Shanghai Jiao Tong University (“our hospital” for short) from June 2015 to December 2018 were selected. According to the diagnostic criteria of PAH, the patients were divided into control group A (COPD without PAH) in 61 cases and observation group (COPD with PAH) in 82 cases. In addition, 40 people with normal lung function who were taken physical examination in our hospital for the same period were selected as the control group B. According to the severity of the condition, the patients with COPD were divided into acute stage (69 cases), remission stage (49 cases), stable stage (25 cases). The observation group was divided into mild PAH group (32 cases), moderate PAH group (27 cases) and severe PAH group (23 cases) according to the degree of increase of pulmonary systolic pressure (PASP). Results The levels of serum VEGF, bFGF and PASP in control group A and observation group were significantly higher than those in control group B, while those in observation group were significantly higher than those in control group A, and the differences were statistically significant (P ＜ 0.05). The levels of VEGF and bFGF in COPD patients in acute stage and remission stage were significantly higher than those in stable stage, while the levels in acute stage were significantly higher than those in remission stage, and the differences were statistically significant (P ＜ 0.05). Serum levels of VEGF and bFGF in moderate PAH group and severe PAH group were significantly lower than those in mild PAH group, while those in severe PAH group were significantly lower than those in moderate PAH group, and the differences were statistically significant (P ＜ 0.05). Serum levels of VEGF and bFGF were positively correlated with PASP in COPD patients without PAH (r = 0.346, 0.438, P = 0.011, 0.006), while serum levels of VEGF and bFGF were negatively correlated with PASP in COPD patients with PAH (r = -0.421, -0.339, P = 0.008, 0.012). Conclusion The levels of serum VEGF and bFGF are abnormally expressed in COPD patients, and their expression levels are closely related to the presence of PASP.

Key words： Vascular endothelial growth factor Basic fibroblast growth factor Chronic obstructive pulmonary disease Pulmonary hypertension Correlation

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	SHEN Hui FEI Xiaoyun GU Xiaohua

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SHEN Hui FEI Xiaoyun GU Xiaohua. The relationship between serum levels of VEGF, bFGF and pulmonary hypertension in patients with chronic obstructive pulmonary disease[J]. 中国医药导报, 2019, 16(26): 125-128.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2019/V16/I26/125

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