预后营养指数与原发性肝癌患者临床病理特征及预后的关系

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Abstract Objective To study the relationship between prognostic nutritional index (PNI) and clinicopathological characteristics and prognosis of patients with primary hepatocellular carcinoma. Methods Ninety patients with primary liver cancer admitted to the Second Affiliated Hospital of Xinjiang Medical University from January 2010 to March 2015 were selected for the study. According to the difference of PNI, 60 cases of low PNI group (PNI < 45) and 30 cases of high PNI group (PNI ≥ 45) were divided into two groups. The relationship between PNI and the general data of patients with primary hepatocellular carcinoma was analyzed. In addition, all patients were followed up for 3 years. The relationship between 3-year overall survival rate and clinicopathological features, PNI and treatment modalities were analyzed. Multivariate Logistic regression analysis was used. Results The proportion of low PNI group with age over 60 years and clinical stage Ⅲ-Ⅳ were higher than those of PNI group, and the differences were statistically significant (all P < 0.05). There were no significant differences in gender, smoking, alcohol consumption and lymph node metastasis between two groups (all P > 0.05). Univariate analysis showed that age, clinical stage, lymph node metastasis, PNI and treatment were all related to the 3-year overall survival rate of patients with primary hepatocellular carcinoma (all P < 0.05). Multivariate Logistic regression analysis showed that age (> 60 years old), clinical stage Ⅲ-Ⅳ, lymph node metastasis, PNI < 45 and non-comprehensive treatment were independent risk factors for 3-year overall survival rate of patients with primary liver cancer (all P < 0.05). Conclusion PNI is closely related to the age and clinical stage of patients with primary hepatocellular carcinoma. In addition, there are many risk factors affecting the prognosis of patients with primary hepatocellular carcinoma. Clinically, such factors should be scientifically monitoring or intervened to better improve the prognosis of patients.

Key words： Primary hepatocellular carcinoma Prognostic nutrition index Clinicopathological features Overall survival rate

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	Ayikeling Nuerbaike1 JI Wenjing2 LI Mengying2 LIANG Cancan2 DING Yongnian2

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Ayikeling Nuerbaike1 JI Wenjing2 LI Mengying2 LIANG Cancan2 DING Yongnian2. The relationship between prognostic nutritional index and clinicopathological characteristics and prognosis of patients with primary hepatocellular carcinoma[J]. 中国医药导报, 2019, 16(26): 117-120.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2019/V16/I26/117

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