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| Effect of Apatinib in the treatment of recurrent extensive small cell lung cancer after multi-line chemotherapy and its impact on the survival of patients |
| ZHANG Haili DONG Guilan LIU Lili GU Xue LYU Lili HU Wanning WANG Zhiwu▲ |
| Department of Radiotherapy and Chemotherapy, Tangshan People′s Hospital, Hebei Province, Tangshan 063000, China |
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Abstract Objective To observe the short-term efficacy, safety and survival of Apatinib in the treatment of patients with extensive small cell lung cancer (SCLC) who had previously undergone multiline chemotherapy. Methods A retrospective study of 62 SCLC patients treated with Apatinib in Department of Radiotherapy and Chemotherapy, Tangshan People′s Hospital from January 2017 to June 2018. The efficacy was evaluated for the first time after 1 cycle (4 weeks). Thereafter, the efficacy was evaluated every two cycles. The primary endpoint was progression-free survival (PFS) and the secondary endpoint was total survival (OS). Kaplan-Meier curve was used to evaluate PFS. Log-rank was used to compare survival differences between groups. The efficacy was evaluated according to RECIST 1.1 criteria, and adverse reactions were evaluated according to CTCAE 4.0 criteria. Results Among the 62 patients with SCLC, there were no CR cases, 11 cases (17.7%) with PR, 37 cases (59.7%) with SD and 14 cases (22.6%) with PD. DCR was 48 cases (77.4%). The median PFS was 3 months (95%CI: 1.13-4.87) and the median OS was 6 months (95%CI: 4.27-7.73). The most common adverse reactions were secondary hypertension (28/62) and hand-foot syndrome (34/62), and grade 3 adverse reactions occurred in 3 cases. Conclusion Apatinib has a definite effect in the third or fourth line treatment of extensive SCLC, and the adverse reactions are tolerable. The results need to be validated in a multi-center, large-sample prospective study.
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